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10.1016/j.thromres.2020.04.013 http://scihub22266oqcxt.onion/10.1016/j.thromres.2020.04.013 32291094!7146714!32291094     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32291094&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Thromb+Res 2020 ; 191 (ä): 145-147 Nephropedia Template TP {{tp|p=32291094|t=2020. Incidence of thrombotic complications in critically ill ICU patients with COVID-19 |pdf=|usr=}}{{32291094}} gab.com Text Incidence of thrombotic complications in critically ill ICU patients with COVID-19 JO: Thromb Res http://www.kidney.de/pget.php?&tw=1&pmid=32291094 #FOAvip INTRODUCTION: COVID-19 may predispose to both venous and arterial thromboembolism due to excessive inflammation, hypoxia, immobilisation and diffuse intravascular coagulation. Reports on the incidence of thrombotic complications are however not available. METHODS: We evaluated the incidence of the composite outcome of symptomatic acute pulmonary embolism (PE), deep-vein thrombosis, ischemic stroke, myocardial infarction or systemic arterial embolism in all COVID-19 patients admitted to the ICU of 2 Dutch university hospitals and 1 Dutch teaching hospital. RESULTS: We studied 184 ICU patients with proven COVID-19 pneumonia of whom 23 died (13%), 22 were discharged alive (12%) and 139 (76%) were still on the ICU on April 5th 2020. All patients received at least standard doses thromboprophylaxis. The cumulative incidence of the composite outcome was 31% (95%CI 20-41), of which CTPA and/or ultrasonography confirmed VTE in 27% (95%CI 17-37%) and arterial thrombotic events in 3.7% (95%CI 0-8.2%). PE was the most frequent thrombotic complication (n = 25, 81%). Age (adjusted hazard ratio (aHR) 1.05/per year, 95%CI 1.004-1.01) and coagulopathy, defined as spontaneous prolongation of the prothrombin time > 3 s or activated partial thromboplastin time > 5 s (aHR 4.1, 95%CI 1.9-9.1), were independent predictors of thrombotic complications. CONCLUSION: The 31% incidence of thrombotic complications in ICU patients with COVID-19 infections is remarkably high. Our findings reinforce the recommendation to strictly apply pharmacological thrombosis prophylaxis in all COVID-19 patients admitted to the ICU, and are strongly suggestive of increasing the prophylaxis towards high-prophylactic doses, even in the absence of randomized evidence. Twit Text FOAVip Incidence of thrombotic complications in critically ill ICU patients with COVID-19 ????Thromb Res http://www.kidney.de/pget.php?&tw=1&pmid=32291094 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32291094 #FOAvip English Wikipedia <ref>{{Cite pmid|32291094}}</ref> Incidence of thrombotic complications in critically ill ICU patients with COVID-19 #MMPMID32291094 Klok FA; Kruip MJHA; van der Meer NJM; Arbous MS; Gommers DAMPJ; Kant KM; Kaptein FHJ; van Paassen J; Stals MAM; Huisman MV; Endeman H Thromb Res 2020[Jul]; 191 (ä): 145-147 PMID32291094show ga INTRODUCTION: COVID-19 may predispose to both venous and arterial thromboembolism due to excessive inflammation, hypoxia, immobilisation and diffuse intravascular coagulation. Reports on the incidence of thrombotic complications are however not available. METHODS: We evaluated the incidence of the composite outcome of symptomatic acute pulmonary embolism (PE), deep-vein thrombosis, ischemic stroke, myocardial infarction or systemic arterial embolism in all COVID-19 patients admitted to the ICU of 2 Dutch university hospitals and 1 Dutch teaching hospital. RESULTS: We studied 184 ICU patients with proven COVID-19 pneumonia of whom 23 died (13%), 22 were discharged alive (12%) and 139 (76%) were still on the ICU on April 5th 2020. All patients received at least standard doses thromboprophylaxis. The cumulative incidence of the composite outcome was 31% (95%CI 20-41), of which CTPA and/or ultrasonography confirmed VTE in 27% (95%CI 17-37%) and arterial thrombotic events in 3.7% (95%CI 0-8.2%). PE was the most frequent thrombotic complication (n = 25, 81%). Age (adjusted hazard ratio (aHR) 1.05/per year, 95%CI 1.004-1.01) and coagulopathy, defined as spontaneous prolongation of the prothrombin time > 3 s or activated partial thromboplastin time > 5 s (aHR 4.1, 95%CI 1.9-9.1), were independent predictors of thrombotic complications. CONCLUSION: The 31% incidence of thrombotic complications in ICU patients with COVID-19 infections is remarkably high. Our findings reinforce the recommendation to strictly apply pharmacological thrombosis prophylaxis in all COVID-19 patients admitted to the ICU, and are strongly suggestive of increasing the prophylaxis towards high-prophylactic doses, even in the absence of randomized evidence. |Acute Disease[MESH] |Anticoagulants/therapeutic use[MESH] |Arterial Occlusive Diseases/*epidemiology/etiology[MESH] |Brain Ischemia/epidemiology/etiology[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications[MESH] |Critical Illness[MESH] |Embolism/epidemiology/etiology[MESH] |Female[MESH] |Hospitals, Teaching/statistics & numerical data[MESH] |Hospitals, University/statistics & numerical data[MESH] |Humans[MESH] |Incidence[MESH] |Male[MESH] |Middle Aged[MESH] |Myocardial Infarction/epidemiology/etiology[MESH] |Netherlands/epidemiology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications[MESH] |Pulmonary Embolism/*epidemiology/etiology[MESH] |Thrombophilia/drug therapy/*etiology[MESH]Incidence of thrombotic complications in critically ill ICU patients w(epmc).pdf DeepDyve Pubget Overpricing