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10.3390/v12040428 http://scihub22266oqcxt.onion/10.3390/v12040428 32290077!7232534!32290077     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2020 ; 12 (4): ä Nephropedia Template TP {{tp|p=32290077|t=2020. Molecular Mechanism of Evolution and Human Infection with SARS-CoV-2 |pdf=|usr=}}{{32290077}} gab.com Text Molecular Mechanism of Evolution and Human Infection with SARS-CoV-2 JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32290077 #FOAvip The outbreak of a novel coronavirus, which was later formally named the severe acute respiratory coronavirus 2 (SARS-CoV-2), has caused a worldwide public health crisis. Previous studies showed that SARS-CoV-2 is highly homologous to SARS-CoV and infects humans through the binding of the spike protein to ACE2. Here, we have systematically studied the molecular mechanisms of human infection with SARS-CoV-2 and SARS-CoV by protein-protein docking and MD simulations. It was found that SARS-CoV-2 binds ACE2 with a higher affinity than SARS-CoV, which may partly explain that SARS-CoV-2 is much more infectious than SARS-CoV. In addition, the spike protein of SARS-CoV-2 has a significantly lower free energy than that of SARS-CoV, suggesting that SARS-CoV-2 is more stable and may survive a higher temperature than SARS-CoV. This provides insights into the evolution of SARS-CoV-2 because SARS-like coronaviruses have originated in bats. Our computation also suggested that the RBD-ACE2 binding for SARS-CoV-2 is much more temperature-sensitive than that for SARS-CoV. Thus, it is expected that SARS-CoV-2 would decrease its infection ability much faster than SARS-CoV when the temperature rises. These findings would be beneficial for the disease prevention and drug/vaccine development of SARS-CoV-2. Twit Text FOAVip Molecular Mechanism of Evolution and Human Infection with SARS-CoV-2 ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32290077 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32290077 #FOAvip English Wikipedia <ref>{{Cite pmid|32290077}}</ref> Molecular Mechanism of Evolution and Human Infection with SARS-CoV-2 #MMPMID32290077 He J; Tao H; Yan Y; Huang SY; Xiao Y Viruses 2020[Apr]; 12 (4): ä PMID32290077show ga The outbreak of a novel coronavirus, which was later formally named the severe acute respiratory coronavirus 2 (SARS-CoV-2), has caused a worldwide public health crisis. Previous studies showed that SARS-CoV-2 is highly homologous to SARS-CoV and infects humans through the binding of the spike protein to ACE2. Here, we have systematically studied the molecular mechanisms of human infection with SARS-CoV-2 and SARS-CoV by protein-protein docking and MD simulations. It was found that SARS-CoV-2 binds ACE2 with a higher affinity than SARS-CoV, which may partly explain that SARS-CoV-2 is much more infectious than SARS-CoV. In addition, the spike protein of SARS-CoV-2 has a significantly lower free energy than that of SARS-CoV, suggesting that SARS-CoV-2 is more stable and may survive a higher temperature than SARS-CoV. This provides insights into the evolution of SARS-CoV-2 because SARS-like coronaviruses have originated in bats. Our computation also suggested that the RBD-ACE2 binding for SARS-CoV-2 is much more temperature-sensitive than that for SARS-CoV. Thus, it is expected that SARS-CoV-2 would decrease its infection ability much faster than SARS-CoV when the temperature rises. These findings would be beneficial for the disease prevention and drug/vaccine development of SARS-CoV-2. |*Biological Evolution[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/*metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/metabolism/*virology[MESH] |Hot Temperature[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH] |Molecular Dynamics Simulation[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*metabolism[MESH] |Pneumonia, Viral/metabolism/*virology[MESH] |Protein Binding[MESH] |Protein Stability[MESH] |SARS-CoV-2[MESH] |Severe acute respiratory syndrome-related coronavirus/metabolism[MESH]Molecular Mechanism of Evolution and Human Infection with SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing