Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1093/molbev/msaa094 http://scihub22266oqcxt.onion/10.1093/molbev/msaa094 32289821!7184484!32289821     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Biol+Evol 2020 ; 37 (9): 2699-2705 Nephropedia Template TP {{tp|p=32289821|t=2020. Extreme Genomic CpG Deficiency in SARS-CoV-2 and Evasion of Host Antiviral Defense |pdf=|usr=}}{{32289821}} gab.com Text Extreme Genomic CpG Deficiency in SARS-CoV-2 and Evasion of Host Antiviral Defense JO: Mol Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=32289821 #FOAvip Wild mammalian species, including bats, constitute the natural reservoir of betacoronavirus (including SARS, MERS, and the deadly SARS-CoV-2). Different hosts or host tissues provide different cellular environments, especially different antiviral and RNA modification activities that can alter RNA modification signatures observed in the viral RNA genome. The zinc finger antiviral protein (ZAP) binds specifically to CpG dinucleotides and recruits other proteins to degrade a variety of viral RNA genomes. Many mammalian RNA viruses have evolved CpG deficiency. Increasing CpG dinucleotides in these low-CpG viral genomes in the presence of ZAP consistently leads to decreased viral replication and virulence. Because ZAP exhibits tissue-specific expression, viruses infecting different tissues are expected to have different CpG signatures, suggesting a means to identify viral tissue-switching events. The author shows that SARS-CoV-2 has the most extreme CpG deficiency in all known betacoronavirus genomes. This suggests that SARS-CoV-2 may have evolved in a new host (or new host tissue) with high ZAP expression. A survey of CpG deficiency in viral genomes identified a virulent canine coronavirus (alphacoronavirus) as possessing the most extreme CpG deficiency, comparable with that observed in SARS-CoV-2. This suggests that the canine tissue infected by the canine coronavirus may provide a cellular environment strongly selecting against CpG. Thus, viral surveys focused on decreasing CpG in viral RNA genomes may provide important clues about the selective environments and viral defenses in the original hosts. Twit Text FOAVip Extreme Genomic CpG Deficiency in SARS-CoV-2 and Evasion of Host Antiviral Defense ????Mol Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=32289821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32289821 #FOAvip English Wikipedia <ref>{{Cite pmid|32289821}}</ref> Extreme Genomic CpG Deficiency in SARS-CoV-2 and Evasion of Host Antiviral Defense #MMPMID32289821 Xia X Mol Biol Evol 2020[Sep]; 37 (9): 2699-2705 PMID32289821show ga Wild mammalian species, including bats, constitute the natural reservoir of betacoronavirus (including SARS, MERS, and the deadly SARS-CoV-2). Different hosts or host tissues provide different cellular environments, especially different antiviral and RNA modification activities that can alter RNA modification signatures observed in the viral RNA genome. The zinc finger antiviral protein (ZAP) binds specifically to CpG dinucleotides and recruits other proteins to degrade a variety of viral RNA genomes. Many mammalian RNA viruses have evolved CpG deficiency. Increasing CpG dinucleotides in these low-CpG viral genomes in the presence of ZAP consistently leads to decreased viral replication and virulence. Because ZAP exhibits tissue-specific expression, viruses infecting different tissues are expected to have different CpG signatures, suggesting a means to identify viral tissue-switching events. The author shows that SARS-CoV-2 has the most extreme CpG deficiency in all known betacoronavirus genomes. This suggests that SARS-CoV-2 may have evolved in a new host (or new host tissue) with high ZAP expression. A survey of CpG deficiency in viral genomes identified a virulent canine coronavirus (alphacoronavirus) as possessing the most extreme CpG deficiency, comparable with that observed in SARS-CoV-2. This suggests that the canine tissue infected by the canine coronavirus may provide a cellular environment strongly selecting against CpG. Thus, viral surveys focused on decreasing CpG in viral RNA genomes may provide important clues about the selective environments and viral defenses in the original hosts. |*Genome, Viral[MESH] |*Pandemics[MESH] |Alphacoronavirus/classification/*genetics/pathogenicity[MESH] |Animals[MESH] |Betacoronavirus/classification/*genetics/pathogenicity[MESH] |Biological Evolution[MESH] |COVID-19[MESH] |Camelus/virology[MESH] |Chiroptera/virology[MESH] |Coronavirus Infections/*epidemiology/immunology/transmission/virology[MESH] |CpG Islands[MESH] |Dogs[MESH] |Hedgehogs/virology[MESH] |Humans[MESH] |Immune Evasion/genetics[MESH] |Mice[MESH] |Pneumonia, Viral/*epidemiology/immunology/transmission/virology[MESH] |Protein Binding[MESH] |RNA, Viral/genetics/metabolism[MESH] |RNA-Binding Proteins/genetics/immunology/metabolism[MESH] |Rabbits[MESH] |Rats[MESH] |Reassortant Viruses/classification/*genetics/pathogenicity[MESH] |SARS-CoV-2[MESH]Extreme Genomic CpG Deficiency in SARS-CoV-2 and Evasion of Host Antiv(epmc).pdf DeepDyve Pubget Overpricing