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10.1016/j.pepo.2013.08.006

http://scihub22266oqcxt.onion/10.1016/j.pepo.2013.08.006
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32287402!7111719!32287402
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suck abstract from ncbi


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pmid32287402      Pediatr+Pol 2013 ; 88 (5): T15-T23
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  • Monoclonal antibodies for prophylactic and therapeutic use against viral infections #MMPMID32287402
  • Both L; Banyard AC; van Dolleweerd C; Wright E; Ma JK; Fooks AR
  • Pediatr Pol 2013[Sep]; 88 (5): T15-T23 PMID32287402show ga
  • Neutralizing antibodies play an essential part in antiviral immunity and are instrumental in preventing or modulating viral diseases. Polyclonal antibody preparations are increasingly being replaced by highly potent monoclonal antibodies (mAbs). Cocktails of mAbs and bispecific constructs can be used to simultaneously target multiple viral epitopes and to overcome issues of neutralization escape. Advances in antibody engineering have led to a large array of novel mAb formats, while deeper insight into the biology of several viruses and increasing knowledge of their neutralizing epitopes has extended the list of potential targets. In addition, progress in developing inexpensive production platforms will make antiviral mAbs more widely available and affordable.
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