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10.2217/fmb-2019-0224

http://scihub22266oqcxt.onion/10.2217/fmb-2019-0224
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32286103!ä!32286103

suck abstract from ncbi


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pmid32286103      Future+Microbiol 2020 ; 15 (ä): 307-317
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  • Persistence of Parvovirus B19 in liver from transplanted patients with acute liver failure #MMPMID32286103
  • Alves AD; Melgaco JG; Cassia Nc Garcia R; Raposo JV; de Paula VS; Araujo CC; Pinto MA; Amado LA
  • Future Microbiol 2020[Mar]; 15 (ä): 307-317 PMID32286103show ga
  • Aim: In this study, we investigated the presence of B19V in liver tissues from patients with acute liver failure (ALF) and evaluated the viral activity in infected liver. Methods: Serum and liver samples from 30 patients who underwent liver transplantation for ALF were investigated for B19V infection by real-time PCR, serological tests and examination of B19V mRNA (transcript) expression in the liver. Results: The serum and liver samples from seven patients were B19V DNA positive (10(3)-10(5) copies/ml). Most of them presented detectable anti-B19V IgG, indicating persistent infection. B19V mRNA was detected in all patients, demonstrating intra-hepatic replication. Conclusion: B19V infection of the liver during the course of non-A-E ALF suggested a role of B19V, which produced the worst outcome in co-infected patients and in patients with cryptogenic ALF, in liver damage.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |Child[MESH]
  • |DNA, Viral/genetics[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Liver Failure, Acute/blood/pathology/therapy/*virology[MESH]
  • |Liver Transplantation[MESH]
  • |Liver/pathology/surgery/virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Parvovirus B19, Human/classification/*genetics/isolation & purification[MESH]
  • |Phylogeny[MESH]


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