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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Future+Microbiol 2020 ; 15 (ä): 307-317 Nephropedia Template TP
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Persistence of Parvovirus B19 in liver from transplanted patients with acute liver failure #MMPMID32286103
Alves AD; Melgaco JG; Cassia Nc Garcia R; Raposo JV; de Paula VS; Araujo CC; Pinto MA; Amado LA
Future Microbiol 2020[Mar]; 15 (ä): 307-317 PMID32286103show ga
Aim: In this study, we investigated the presence of B19V in liver tissues from patients with acute liver failure (ALF) and evaluated the viral activity in infected liver. Methods: Serum and liver samples from 30 patients who underwent liver transplantation for ALF were investigated for B19V infection by real-time PCR, serological tests and examination of B19V mRNA (transcript) expression in the liver. Results: The serum and liver samples from seven patients were B19V DNA positive (10(3)-10(5) copies/ml). Most of them presented detectable anti-B19V IgG, indicating persistent infection. B19V mRNA was detected in all patients, demonstrating intra-hepatic replication. Conclusion: B19V infection of the liver during the course of non-A-E ALF suggested a role of B19V, which produced the worst outcome in co-infected patients and in patients with cryptogenic ALF, in liver damage.