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Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Eur+J+Med+Chem 2020 ; 195 (ä): 112275 Nephropedia Template TP
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A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery #MMPMID32283298
Pillaiyar T; Meenakshisundaram S; Manickam M; Sankaranarayanan M
Eur J Med Chem 2020[Jun]; 195 (ä): 112275 PMID32283298show ga
Drug repurposing is a strategy consisting of finding new indications for already known marketed drugs used in various clinical settings or highly characterized compounds despite they can be failed drugs. Recently, it emerges as an alternative approach for the rapid identification and development of new pharmaceuticals for various rare and complex diseases for which lack the effective drug treatments. The success rate of drugs repurposing approach accounts for approximately 30% of new FDA approved drugs and vaccines in recent years. This review focuses on the status of drugs repurposing approach for various diseases including skin diseases, infective, inflammatory, cancer, and neurodegenerative diseases. Efforts have been made to provide structural features and mode of actions of drugs.