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10.1016/j.jinf.2020.03.062 http://scihub22266oqcxt.onion/10.1016/j.jinf.2020.03.062 32283144!7195158!32283144     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32283144&cmd=llinks): Failed to open stream: HTTP request failed! 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The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis |pdf=|usr=}}{{32283144}} gab.com Text The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis JO: J Infect http://www.kidney.de/pget.php?&tw=1&pmid=32283144 #FOAvip OBJECTIVES: An outbreak of novel coronavirus in 2019 threatens the health of people, and there is no proven pharmacological treatment. Although corticosteroids were widely used during outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome, their efficacy remainedhighly controversial. We aimed to further evaluate the influence of corticosteroids on patients with coronavirus infection. METHODS: We conducted a comprehensive search of literature published in PubMed, Embase, Cochrane library, and China National Knowledge Infrastructure (CNKI) from January 1, 2002 to March 15, 2020. All statistical analyses in this study were performed on stata14.0. RESULTS: A total of 5270 patients from 15 studies were included in this meta-analysis. The result indicated that critical patients were more likely to require corticosteroids therapy (risk ratio [RR]?=?1.56, 95% confidence interval [CI]?=?1.28-1.90, P<0.001). However, corticosteroid treatment was associated with higher mortality (RR?=?2.11, 95%CI?=?1.13-3.94, P?=?0.019), longer length of stay (weighted mean difference [WMD]?=?6.31, 95%CI?=?5.26-7.37, P<0.001), a higher rate of bacterial infection (RR?=?2.08, 95%CI?=?1.54-2.81, P<0.001), and hypokalemia (RR?=?2.21, 95%CI?=?1.07-4.55, P?=?0.032) but not hyperglycemia (RR?=?1.37, 95%CI=0.68-2.76, P = 0.376) or hypocalcemia (RR?=?1.35, 95%CI?=?0.77-2.37, P?=?0.302). CONCLUSIONS: Patients with severe conditions are more likely to require corticosteroids. Corticosteroid use is associated with increased mortality in patients with coronavirus pneumonia. Twit Text FOAVip The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis ????J Infect http://www.kidney.de/pget.php?&tw=1&pmid=32283144 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32283144 #FOAvip English Wikipedia <ref>{{Cite pmid|32283144}}</ref> The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis #MMPMID32283144 Yang Z; Liu J; Zhou Y; Zhao X; Zhao Q; Liu J J Infect 2020[Jul]; 81 (1): e13-e20 PMID32283144show ga OBJECTIVES: An outbreak of novel coronavirus in 2019 threatens the health of people, and there is no proven pharmacological treatment. Although corticosteroids were widely used during outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome, their efficacy remainedhighly controversial. We aimed to further evaluate the influence of corticosteroids on patients with coronavirus infection. METHODS: We conducted a comprehensive search of literature published in PubMed, Embase, Cochrane library, and China National Knowledge Infrastructure (CNKI) from January 1, 2002 to March 15, 2020. All statistical analyses in this study were performed on stata14.0. RESULTS: A total of 5270 patients from 15 studies were included in this meta-analysis. The result indicated that critical patients were more likely to require corticosteroids therapy (risk ratio [RR]?=?1.56, 95% confidence interval [CI]?=?1.28-1.90, P<0.001). However, corticosteroid treatment was associated with higher mortality (RR?=?2.11, 95%CI?=?1.13-3.94, P?=?0.019), longer length of stay (weighted mean difference [WMD]?=?6.31, 95%CI?=?5.26-7.37, P<0.001), a higher rate of bacterial infection (RR?=?2.08, 95%CI?=?1.54-2.81, P<0.001), and hypokalemia (RR?=?2.21, 95%CI?=?1.07-4.55, P?=?0.032) but not hyperglycemia (RR?=?1.37, 95%CI=0.68-2.76, P = 0.376) or hypocalcemia (RR?=?1.35, 95%CI?=?0.77-2.37, P?=?0.302). CONCLUSIONS: Patients with severe conditions are more likely to require corticosteroids. Corticosteroid use is associated with increased mortality in patients with coronavirus pneumonia. |*Betacoronavirus[MESH] |Adrenal Cortex Hormones/*therapeutic use[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/mortality/virology[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/mortality/virology[MESH]The effect of corticosteroid treatment on patients with coronavirus in(epmc).pdf DeepDyve Pubget Overpricing