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10.1111/ajt.15915

http://scihub22266oqcxt.onion/10.1111/ajt.15915
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32282982!7262146!32282982
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suck abstract from ncbi


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pmid32282982      Am+J+Transplant 2020 ; 20 (7): 1809-1818
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  • Early impact of COVID-19 on transplant center practices and policies in the United States #MMPMID32282982
  • Boyarsky BJ; Po-Yu Chiang T; Werbel WA; Durand CM; Avery RK; Getsin SN; Jackson KR; Kernodle AB; Van Pilsum Rasmussen SE; Massie AB; Segev DL; Garonzik-Wang JM
  • Am J Transplant 2020[Jul]; 20 (7): 1809-1818 PMID32282982show ga
  • COVID-19 is a novel, rapidly changing pandemic: consequently, evidence-based recommendations in solid organ transplantation (SOT) remain challenging and unclear. To understand the impact on transplant activity across the United States, and center-level variation in testing, clinical practice, and policies, we conducted a national survey between March 24, 2020 and March 31, 2020 and linked responses to the COVID-19 incidence map. Response rate was a very high 79.3%, reflecting a strong national priority to better understand COVID-19. Complete suspension of live donor kidney transplantation was reported by 71.8% and live donor liver by 67.7%. While complete suspension of deceased donor transplantation was less frequent, some restrictions to deceased donor kidney transplantation were reported by 84.0% and deceased donor liver by 73.3%; more stringent restrictions were associated with higher regional incidence of COVID-19. Shortage of COVID-19 tests was reported by 42.5%. Respondents reported a total of 148 COVID-19 recipients from <1 to >10 years posttransplant: 69.6% were kidney recipients, and 25.0% were critically ill. Hydroxychloroquine (HCQ) was used by 78.1% of respondents; azithromycin by 46.9%; tocilizumab by 31.3%, and remdesivir by 25.0%. There is wide heterogeneity in center-level response across the United States; ongoing national data collection, expert discussion, and clinical studies are critical to informing evidence-based practices.
  • |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH]
  • |Alanine/analogs & derivatives/therapeutic use[MESH]
  • |Antibodies, Monoclonal, Humanized/therapeutic use[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques/statistics & numerical data[MESH]
  • |Coronavirus Infections/diagnosis/drug therapy/*prevention & control/*transmission[MESH]
  • |Critical Illness[MESH]
  • |Evidence-Based Medicine[MESH]
  • |Health Policy[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Incidence[MESH]
  • |Kidney Failure, Chronic/complications/surgery[MESH]
  • |Kidney Transplantation/statistics & numerical data/trends[MESH]
  • |Liver Transplantation/statistics & numerical data/trends[MESH]
  • |Living Donors[MESH]
  • |Organ Transplantation/legislation & jurisprudence/statistics & numerical data/*trends[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/*prevention & control/*transmission[MESH]
  • |Resource Allocation[MESH]
  • |SARS-CoV-2[MESH]
  • |Surveys and Questionnaires[MESH]
  • |Tissue Donors[MESH]
  • |Transplant Recipients[MESH]


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