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10.1002/alr.22579

http://scihub22266oqcxt.onion/10.1002/alr.22579
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32279441!7262089!32279441
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suck abstract from ncbi


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pmid32279441      Int+Forum+Allergy+Rhinol 2020 ; 10 (7): 806-813
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  • Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms #MMPMID32279441
  • Yan CH; Faraji F; Prajapati DP; Boone CE; DeConde AS
  • Int Forum Allergy Rhinol 2020[Jul]; 10 (7): 806-813 PMID32279441show ga
  • BACKGROUND: Rapid spread of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and concern for viral transmission by ambulatory patients with minimal to no symptoms underline the importance of identifying early or subclinical symptoms of coronavirus disease 2019 (COVID-19) infection. Two such candidate symptoms include anecdotally reported loss of smell and taste. Understanding the timing and association of smell/taste loss in COVID-19 may help facilitate screening and early isolation of cases. METHODS: A single-institution, cross-sectional study evaluating patient-reported symptoms with a focus on smell and taste was conducted using an internet-based platform on adult subjects who underwent testing for COVID-19. Logistic regression was employed to identify symptoms associated with COVID-19 positivity. RESULTS: A total of 1480 patients with influenza-like symptoms underwent COVID-19 testing between March 3, 2020, and March 29, 2020. Our study captured 59 of 102 (58%) COVID-19-positive patients and 203 of 1378 (15%) COVID-19-negative patients. Smell and taste loss were reported in 68% (40/59) and 71% (42/59) of COVID-19-positive subjects, respectively, compared to 16% (33/203) and 17% (35/203) of COVID-19-negative patients (p < 0.001). Smell and taste impairment were independently and strongly associated with COVID-19 positivity (anosmia: adjusted odds ratio [aOR] 10.9; 95% CI, 5.08-23.5; ageusia: aOR 10.2; 95% CI, 4.74-22.1), whereas sore throat was associated with COVID-19 negativity (aOR 0.23; 95% CI, 0.11-0.50). Of patients who reported COVID-19-associated loss of smell, 74% (28/38) reported resolution of anosmia with clinical resolution of illness. CONCLUSION: In ambulatory individuals with influenza-like symptoms, chemosensory dysfunction was strongly associated with COVID-19 infection and should be considered when screening symptoms. Most will recover chemosensory function within weeks, paralleling resolution of other disease-related symptoms.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/diagnosis/epidemiology/physiopathology[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Olfaction Disorders/diagnosis/epidemiology/*etiology/physiopathology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/diagnosis/epidemiology/physiopathology[MESH]
  • |Prevalence[MESH]
  • |SARS-CoV-2[MESH]
  • |Taste Disorders/diagnosis/epidemiology/*etiology/physiopathology[MESH]


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