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10.1016/j.lfs.2020.117652

http://scihub22266oqcxt.onion/10.1016/j.lfs.2020.117652
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32278693!7194845!32278693
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suck abstract from ncbi


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pmid32278693      Life+Sci 2020 ; 252 (ä): 117652
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  • In silico studies on therapeutic agents for COVID-19: Drug repurposing approach #MMPMID32278693
  • Shah B; Modi P; Sagar SR
  • Life Sci 2020[Jul]; 252 (ä): 117652 PMID32278693show ga
  • AIMS: The severe acute respiratory syndrome coronavirus 2, better known as COVID-19 has become the current health concern to the entire world. Initially appeared in Wuhan, China around December 2019, it had spread to almost 187 countries due to its high contagious nature. Precautionary measures remain the sole obliging tactic to cease the person to person transmissions till any effective method of treatment or vaccine is developed. Amidst the pandemic, research and development of new molecule is labour-intensive and tedious process. Drug repurposing is the concept of identifying therapeutically potent molecule from the library of pre-existing molecules. MATERIALS AND METHODS: In the present study, 61 molecules that are already being used in clinics or under clinical scrutiny as antiviral agents are surveyed via docking study. Docking study was performed using Maestro interface (Schrodinger Suite, LLC, NY). KEY FINDINGS: Out of these 61 molecules, 37 molecules were found to interact with >2 protein structures of COVID-19. The docking results indicate that amongst the reported molecules, HIV protease inhibitors and RNA-dependent RNA polymerase inhibitors showed promising features of binding to COVID-19 enzyme. Along with these, Methisazone an inhibitor of protein synthesis, CGP42112A an angiotensin AT2 receptor agonist and ABT450 an inhibitor of the non-structural protein 3-4A might become convenient treatment option as well against COVID-19. SIGNIFICANCE: The drug repurposing approach provide an insight about the therapeutics that might be helpful in treating corona virus disease.
  • |*Drug Repositioning[MESH]
  • |Antiviral Agents/*chemistry[MESH]
  • |Betacoronavirus/*enzymology[MESH]
  • |COVID-19[MESH]
  • |Computer Simulation[MESH]
  • |Coronavirus 3C Proteases[MESH]
  • |Coronavirus Infections/drug therapy/virology[MESH]
  • |Cysteine Endopeptidases/*chemistry[MESH]
  • |Molecular Docking Simulation[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/drug therapy/virology[MESH]
  • |SARS-CoV-2[MESH]


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