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10.1016/j.accpm.2020.04.001

http://scihub22266oqcxt.onion/10.1016/j.accpm.2020.04.001
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32278670!7144603!32278670
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suck abstract from ncbi


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pmid32278670      Anaesth+Crit+Care+Pain+Med 2020 ; 39 (5): 553-561
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  • SARS-CoV-2 in Spanish Intensive Care Units: Early experience with 15-day survival in Vitoria #MMPMID32278670
  • Barrasa H; Rello J; Tejada S; Martin A; Balziskueta G; Vinuesa C; Fernandez-Miret B; Villagra A; Vallejo A; San Sebastian A; Cabanes S; Iribarren S; Fonseca F; Maynar J
  • Anaesth Crit Care Pain Med 2020[Oct]; 39 (5): 553-561 PMID32278670show ga
  • PURPOSE: Community transmission of SARS-CoV-2 was detected in Spain in February 2020, with 216% intensive care unit (ICU) capacity expanded in Vitoria by March 18(th), 2020. METHODS: We identified patients from the two public hospitals in Vitoria who were admitted to ICU with confirmed infection by SARS-CoV-2. Data reported here were available in April 6th, 2020. Mortality was assessed in those who completed 15-days of ICU stay. RESULTS: We identified 48 patients (27 males) with confirmed SARS-CoV-2. Median [interquartile range (IQR)] age of patients was 63 [51-75] years. Symptoms began a median of 7 [5-12] days before ICU admission. The most common comorbidities identified were obesity (48%), arterial hypertension (44%) and chronic lung disease (37%). All patients were admitted by hypoxemic respiratory failure and none received non-invasive mechanical ventilation. Forty-five (94%) underwent intubation, 3 (6%) high flow nasal therapy (HFNT), 1 (2%) extracorporeal membrane oxygenation (ECMO) and 22 (46%) required prone position. After 15 days, 14/45 (31%) intubated patients died (13% within one week), 10/45 (22%) were extubated, and 21/45 (47%) underwent mechanical ventilation. Six patients had documented super-infection. Procalcitonin plasma above 0.5mug/L was associated with 16% vs. 19% (p=0.78) risk of death after 7 days. CONCLUSION: This early experience with SARS-CoV-2 in Spain suggests that a strategy of right oxygenation avoiding non-invasive mechanical ventilation was life-saving. Seven-day mortality in SARS-CoV-2 requiring intubation was lower than 15%, with 80% of patients still requiring mechanical ventilation. After 15 days of ICU admission, half of patients remained intubated, whereas one third died.
  • |*Betacoronavirus[MESH]
  • |*Pandemics[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Combined Modality Therapy[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/blood/complications/drug therapy/*mortality/therapy[MESH]
  • |Disease Outbreaks[MESH]
  • |Female[MESH]
  • |Hospital Mortality[MESH]
  • |Hospitals, Public/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Influenza, Human/epidemiology[MESH]
  • |Intensive Care Units/*statistics & numerical data[MESH]
  • |Kaplan-Meier Estimate[MESH]
  • |Length of Stay[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Oxygen Inhalation Therapy[MESH]
  • |Pneumonia, Viral/blood/complications/*mortality/therapy[MESH]
  • |Procalcitonin/blood[MESH]
  • |Respiration, Artificial[MESH]
  • |Respiratory Distress Syndrome/etiology/mortality/therapy[MESH]
  • |SARS-CoV-2[MESH]


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