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10.4414/smw.2020.20246

http://scihub22266oqcxt.onion/10.4414/smw.2020.20246
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32277836!ä!32277836

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suck abstract from ncbi


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pmid32277836      Swiss+Med+Wkly 2020 ; 150 (ä): w20246
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  • Benign COVID-19 in an immunocompromised cancer patient - the case of a married couple #MMPMID32277836
  • Spezzani V; Piunno A; Iselin HU
  • Swiss Med Wkly 2020[Apr]; 150 (ä): w20246 PMID32277836show ga
  • Respiratory failure in COVID-19 is a common feature in fatal cases and has been considered as a failure of the immune system to control the virus. Here we report the case of COVID-19 affecting an immunocompromised women and her presumably immunocompetent spouse. A married couple (age 60 years) was simultaneously admitted to the emergency department on 10 March 2020 because of dyspnoea and fever, consistent with COVID-19. The wife (patient 1) was partially immunocompromised as a consequence of a recently started chemotherapy with fulvestrant and abemaciclid for recurring breast cancer, her husband (patient 2) had been healthy except for a history of controlled arterial hypertension. Both patients were treated with darunavir/cobicistat and hydroxychloroquine. The clinical course of the immunocompromised partner was benign, without need of intensive care. She was able to leave the hospital on day 6 after admission. In contrast, her husband needed intensive care and his recovery was slow, although eventually successful too. These findings suggest that the course of COVID-19 is not necessarily ominous in the presence of a compromised immune response and tend to reinforce the emerging therapeutic concepts of a controlled mitigation of the immune cascade following SARS CoV-2 infection.
  • |Anti-Bacterial Agents/*therapeutic use[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Betacoronavirus[MESH]
  • |Breast Neoplasms/*complications[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Cobicistat/*therapeutic use[MESH]
  • |Coronavirus Infections/*drug therapy/virology[MESH]
  • |Critical Care[MESH]
  • |Darunavir/*therapeutic use[MESH]
  • |Dyspnea/etiology[MESH]
  • |Emergency Service, Hospital[MESH]
  • |Female[MESH]
  • |Fever/etiology[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*therapeutic use[MESH]
  • |Immunocompetence[MESH]
  • |Immunocompromised Host[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Neoplasm Recurrence, Local/drug therapy[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Spouses[MESH]


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