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10.1007/s15010-020-01424-5

http://scihub22266oqcxt.onion/10.1007/s15010-020-01424-5
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32277408!7146072!32277408
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suck abstract from ncbi


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pmid32277408      Infection 2020 ; 48 (5): 773-777
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  • First case of COVID-19 complicated with fulminant myocarditis: a case report and insights #MMPMID32277408
  • Zeng JH; Liu YX; Yuan J; Wang FX; Wu WB; Li JX; Wang LF; Gao H; Wang Y; Dong CF; Li YJ; Xie XJ; Feng C; Liu L
  • Infection 2020[Oct]; 48 (5): 773-777 PMID32277408show ga
  • BACKGROUND: Coronavirus disease 2019 (COVID-19) has been demonstrated to be the cause of pneumonia. Nevertheless, it has not been reported as the cause of acute myocarditis or fulminant myocarditis. CASE PRESENTATION: A 63-year-old male was admitted with pneumonia and cardiac symptoms. He was genetically confirmed as having COVID-19 according to sputum testing on the day of admission. He also had elevated troponin I (Trop I) level (up to 11.37 g/L) and diffuse myocardial dyskinesia along with a decreased left ventricular ejection fraction (LVEF) on echocardiography. The highest level of interleukin-6 was 272.40 pg/ml. Bedside chest radiographs showed typical ground-glass changes indicative of viral pneumonia. Laboratory test results for viruses that cause myocarditis were all negative. The patient conformed to the diagnostic criteria of the Chinese expert consensus statement for fulminant myocarditis. After receiving antiviral therapy and mechanical life support, Trop I was reduced to 0.10 g/L, and interleukin-6 was reduced to 7.63 pg/mL. Moreover, the LVEF of the patient gradually recovered to 68%. The patient died of aggravation of secondary infection on the 33rd day of hospitalization. CONCLUSION: COVID-19 patients may develop severe cardiac complications such as myocarditis and heart failure. This is the first report of COVID-19 complicated with fulminant myocarditis. The mechanism of cardiac pathology caused by COVID-19 needs further study.
  • |Acute Disease[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Bacteroides Infections/*complications/diagnostic imaging/drug therapy/virology[MESH]
  • |Betacoronavirus/drug effects/*pathogenicity[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19[MESH]
  • |Candidiasis/*complications/diagnostic imaging/drug therapy/virology[MESH]
  • |Coronavirus Infections/*complications/diagnostic imaging/drug therapy/virology[MESH]
  • |Drug Combinations[MESH]
  • |Echocardiography[MESH]
  • |Fatal Outcome[MESH]
  • |Humans[MESH]
  • |Interleukin-6/blood[MESH]
  • |Lopinavir/therapeutic use[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Myocarditis/*complications/diagnostic imaging/drug therapy/virology[MESH]
  • |Pandemics[MESH]
  • |Piperacillin, Tazobactam Drug Combination/therapeutic use[MESH]
  • |Pneumonia, Viral/*complications/diagnostic imaging/drug therapy/virology[MESH]
  • |Ritonavir/therapeutic use[MESH]
  • |SARS-CoV-2[MESH]
  • |Stroke Volume/drug effects[MESH]
  • |Tomography, X-Ray Computed[MESH]


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