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10.1074/jbc.H120.013397

http://scihub22266oqcxt.onion/10.1074/jbc.H120.013397
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32277065!7152748!32277065
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suck abstract from ncbi

pmid32277065      J+Biol+Chem 2020 ; 295 (15): 4780-4781
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  • Halting coronavirus polymerase #MMPMID32277065
  • Kirchdoerfer RN
  • J Biol Chem 2020[Apr]; 295 (15): 4780-4781 PMID32277065show ga
  • The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.
  • |Adenosine Monophosphate/*analogs & derivatives/pharmacology[MESH]
  • |Alanine/*analogs & derivatives/pharmacology[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/*pharmacology[MESH]
  • |Coronavirus Infections/*drug therapy/virology[MESH]
  • |Coronavirus/*drug effects/*enzymology/physiology[MESH]
  • |Exonucleases[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |RNA-Dependent RNA Polymerase/*antagonists & inhibitors[MESH]


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