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10.1158/2159-8290.CD-20-0451

http://scihub22266oqcxt.onion/10.1158/2159-8290.CD-20-0451
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32276929!7437472!32276929
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suck abstract from ncbi


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pmid32276929      Cancer+Discov 2020 ; 10 (6): 779-782
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  • TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention? #MMPMID32276929
  • Stopsack KH; Mucci LA; Antonarakis ES; Nelson PS; Kantoff PW
  • Cancer Discov 2020[Jun]; 10 (6): 779-782 PMID32276929show ga
  • TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.
  • |Betacoronavirus/*drug effects[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/drug therapy/*genetics/mortality/prevention & control[MESH]
  • |Esters[MESH]
  • |Female[MESH]
  • |Gabexate/analogs & derivatives/pharmacology[MESH]
  • |Gene Expression Regulation[MESH]
  • |Genetic Predisposition to Disease[MESH]
  • |Guanidines[MESH]
  • |Humans[MESH]
  • |Influenza, Human/genetics[MESH]
  • |Male[MESH]
  • |Pandemics/prevention & control[MESH]
  • |Pneumonia, Viral/drug therapy/*genetics/mortality/prevention & control[MESH]
  • |Prostatic Neoplasms/genetics/pathology[MESH]
  • |SARS-CoV-2[MESH]
  • |Serine Endopeptidases/*genetics[MESH]


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