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TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention? #MMPMID32276929
Stopsack KH; Mucci LA; Antonarakis ES; Nelson PS; Kantoff PW
Cancer Discov 2020[Jun]; 10 (6): 779-782 PMID32276929show ga
TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.