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10.1016/j.antiviral.2020.104792 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2020.104792 32272173!7194977!32272173     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2020 ; 178 (ä): 104792 Nephropedia Template TP {{tp|p=32272173|t=2020. Coronavirus membrane fusion mechanism offers a potential target for antiviral development |pdf=|usr=}}{{32272173}} gab.com Text Coronavirus membrane fusion mechanism offers a potential target for antiviral development JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=32272173 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the need to develop effective therapies against the causative agent, SARS-CoV-2, and also against other pathogenic coronaviruses (CoV) that have emerged in the past or might appear in future. Researchers are therefore focusing on steps in the CoV replication cycle that may be vulnerable to inhibition by broad-spectrum or specific antiviral agents. The conserved nature of the fusion domain and mechanism across the CoV family make it a valuable target to elucidate and develop pan-CoV therapeutics. In this article, we review the role of the CoV spike protein in mediating fusion of the viral and host cell membranes, summarizing the results of research on SARS-CoV, MERS-CoV, and recent peer-reviewed studies of SARS-CoV-2, and suggest that the fusion mechanism be investigated as a potential antiviral target. We also provide a supplemental file containing background information on the biology, epidemiology, and clinical features of all human-infecting coronaviruses, along with a phylogenetic tree of these coronaviruses. Twit Text FOAVip Coronavirus membrane fusion mechanism offers a potential target for antiviral development ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=32272173 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32272173 #FOAvip English Wikipedia <ref>{{Cite pmid|32272173}}</ref> Coronavirus membrane fusion mechanism offers a potential target for antiviral development #MMPMID32272173 Tang T; Bidon M; Jaimes JA; Whittaker GR; Daniel S Antiviral Res 2020[Jun]; 178 (ä): 104792 PMID32272173show ga The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the need to develop effective therapies against the causative agent, SARS-CoV-2, and also against other pathogenic coronaviruses (CoV) that have emerged in the past or might appear in future. Researchers are therefore focusing on steps in the CoV replication cycle that may be vulnerable to inhibition by broad-spectrum or specific antiviral agents. The conserved nature of the fusion domain and mechanism across the CoV family make it a valuable target to elucidate and develop pan-CoV therapeutics. In this article, we review the role of the CoV spike protein in mediating fusion of the viral and host cell membranes, summarizing the results of research on SARS-CoV, MERS-CoV, and recent peer-reviewed studies of SARS-CoV-2, and suggest that the fusion mechanism be investigated as a potential antiviral target. We also provide a supplemental file containing background information on the biology, epidemiology, and clinical features of all human-infecting coronaviruses, along with a phylogenetic tree of these coronaviruses. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Betacoronavirus/*drug effects/physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/drug therapy/virology[MESH] |Humans[MESH] |Membrane Fusion/*drug effects[MESH] |Molecular Targeted Therapy[MESH] |Pandemics[MESH] |Pneumonia, Viral/drug therapy/virology[MESH] |SARS-CoV-2[MESH]Coronavirus membrane fusion mechanism offers a potential target for an(epmc).pdf DeepDyve Pubget Overpricing