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Phylogenetic network analysis of SARS-CoV-2 genomes #MMPMID32269081
Forster P; Forster L; Renfrew C; Forster M
Proc Natl Acad Sci U S A 2020[Apr]; 117 (17): 9241-9243 PMID32269081show ga
In a phylogenetic network analysis of 160 complete human severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) genomes, we find three central variants distinguished by amino acid changes, which we have named A, B, and C, with A being the ancestral type according to the bat outgroup coronavirus. The A and C types are found in significant proportions outside East Asia, that is, in Europeans and Americans. In contrast, the B type is the most common type in East Asia, and its ancestral genome appears not to have spread outside East Asia without first mutating into derived B types, pointing to founder effects or immunological or environmental resistance against this type outside Asia. The network faithfully traces routes of infections for documented coronavirus disease 2019 (COVID-19) cases, indicating that phylogenetic networks can likewise be successfully used to help trace undocumented COVID-19 infection sources, which can then be quarantined to prevent recurrent spread of the disease worldwide.
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Proc+Natl+Acad+Sci+U+S+A 2020 ; 117 (17): 9241-9243
