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10.1016/j.chom.2020.03.023 http://scihub22266oqcxt.onion/10.1016/j.chom.2020.03.023 32259477!7144857!32259477     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2020 ; 27 (5): 704-709.e2 Nephropedia Template TP {{tp|p=32259477|t=2020. Infection and Rapid Transmission of SARS-CoV-2 in Ferrets |pdf=|usr=}}{{32259477}} gab.com Text Infection and Rapid Transmission of SARS-CoV-2 in Ferrets JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=32259477 #FOAvip The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China and rapidly spread worldwide. To prevent SARS-CoV-2 dissemination, understanding the in vivo characteristics of SARS-CoV-2 is a high priority. We report a ferret model of SARS-CoV-2 infection and transmission that recapitulates aspects of human disease. SARS-CoV-2-infected ferrets exhibit elevated body temperatures and virus replication. Although fatalities were not observed, SARS-CoV-2-infected ferrets shed virus in nasal washes, saliva, urine, and feces up to 8 days post-infection. At 2 days post-contact, SARS-CoV-2 was detected in all naive direct contact ferrets. Furthermore, a few naive indirect contact ferrets were positive for viral RNA, suggesting airborne transmission. Viral antigens were detected in nasal turbinate, trachea, lungs, and intestine with acute bronchiolitis present in infected lungs. Thus, ferrets represent an infection and transmission animal model of COVID-19 that may facilitate development of SARS-CoV-2 therapeutics and vaccines. Twit Text FOAVip Infection and Rapid Transmission of SARS-CoV-2 in Ferrets ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=32259477 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32259477 #FOAvip English Wikipedia <ref>{{Cite pmid|32259477}}</ref> Infection and Rapid Transmission of SARS-CoV-2 in Ferrets #MMPMID32259477 Kim YI; Kim SG; Kim SM; Kim EH; Park SJ; Yu KM; Chang JH; Kim EJ; Lee S; Casel MAB; Um J; Song MS; Jeong HW; Lai VD; Kim Y; Chin BS; Park JS; Chung KH; Foo SS; Poo H; Mo IP; Lee OJ; Webby RJ; Jung JU; Choi YK Cell Host Microbe 2020[May]; 27 (5): 704-709.e2 PMID32259477show ga The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China and rapidly spread worldwide. To prevent SARS-CoV-2 dissemination, understanding the in vivo characteristics of SARS-CoV-2 is a high priority. We report a ferret model of SARS-CoV-2 infection and transmission that recapitulates aspects of human disease. SARS-CoV-2-infected ferrets exhibit elevated body temperatures and virus replication. Although fatalities were not observed, SARS-CoV-2-infected ferrets shed virus in nasal washes, saliva, urine, and feces up to 8 days post-infection. At 2 days post-contact, SARS-CoV-2 was detected in all naive direct contact ferrets. Furthermore, a few naive indirect contact ferrets were positive for viral RNA, suggesting airborne transmission. Viral antigens were detected in nasal turbinate, trachea, lungs, and intestine with acute bronchiolitis present in infected lungs. Thus, ferrets represent an infection and transmission animal model of COVID-19 that may facilitate development of SARS-CoV-2 therapeutics and vaccines. |*Ferrets[MESH] |Animals[MESH] |Antibodies, Viral/immunology[MESH] |Betacoronavirus/immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*pathology/*transmission[MESH] |Disease Models, Animal[MESH] |Pandemics[MESH] |Pneumonia, Viral/*pathology/*transmission[MESH] |SARS-CoV-2[MESH] |Viral Vaccines/immunology[MESH]Infection and Rapid Transmission of SARS-CoV-2 in Ferrets (epmc).pdf DeepDyve Pubget Overpricing