Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/chem.202000481 http://scihub22266oqcxt.onion/10.1002/chem.202000481 32253776!ä!32253776 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chemistry 2020 ; 26 (51): 11782-11795 Nephropedia Template TP {{tp|p=32253776|t=2020. Synthesis and Binding of Mannose-Specific Synthetic Carbohydrate Receptors |pdf=|usr=}}{{32253776}} gab.com Text Synthesis and Binding of Mannose-Specific Synthetic Carbohydrate Receptors JO: Chemistry http://www.kidney.de/pget.php?&tw=1&pmid=32253776 #FOAvip Synthetic carbohydrate receptors (SCRs) that selectively recognize cell-surface glycans could be used for detection, drug delivery, or as therapeutics. Here we report the synthesis of seven new C(2h) symmetric tetrapodal SCRs. The structures of these SCRs possess a conserved biaryl core, and they vary in the four heterocyclic binding groups that are linked to the biaryl core via secondary amines. Supramolecular association between these SCRs and five biologically relevant C(1) -O-octyloxy glycans, alpha/beta-glucoside (alpha/beta-Glc), alpha/beta-mannoside (alpha/beta-Man), and beta-galactoside (beta-Gal), was studied by mass spectrometry, (1) H NMR titrations, and molecular modeling. These studies revealed that selectivity can be achieved in these tetrapodal SCRs by varying the heterocyclic binding group. We found that SCR017 (3-pyrrole), SCR021 (3-pyridine), and SCR022 (2-phenol) bind only to beta-Glc. SCR019 (3-indole) binds only to beta-Man. SCR020 (2-pyridine) binds beta-Man and alpha-Man with a preference to the latter. SCR018 (2-indole) binds alpha-Man and beta-Gal with a preference to the former. The glycan guests bound within their SCR hosts in one of three supramolecular geometries: center-parallel, center-perpendicular, and off-center. Many host-guest combinations formed higher stoichiometry complexes, 2:1 glycan?SCR or 1:2 glycan?SCR, where the former are driven by positive allosteric cooperativity induced by glycan-glycan contacts. Twit Text FOAVip Synthesis and Binding of Mannose-Specific Synthetic Carbohydrate Receptors ????Chemistry http://www.kidney.de/pget.php?&tw=1&pmid=32253776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32253776 #FOAvip English Wikipedia <ref>{{Cite pmid|32253776}}</ref> Synthesis and Binding of Mannose-Specific Synthetic Carbohydrate Receptors #MMPMID32253776 Bravo MF; Palanichamy K; Shlain MA; Schiro F; Naeem Y; Marianski M; Braunschweig AB Chemistry 2020[Sep]; 26 (51): 11782-11795 PMID32253776show ga Synthetic carbohydrate receptors (SCRs) that selectively recognize cell-surface glycans could be used for detection, drug delivery, or as therapeutics. Here we report the synthesis of seven new C(2h) symmetric tetrapodal SCRs. The structures of these SCRs possess a conserved biaryl core, and they vary in the four heterocyclic binding groups that are linked to the biaryl core via secondary amines. Supramolecular association between these SCRs and five biologically relevant C(1) -O-octyloxy glycans, alpha/beta-glucoside (alpha/beta-Glc), alpha/beta-mannoside (alpha/beta-Man), and beta-galactoside (beta-Gal), was studied by mass spectrometry, (1) H NMR titrations, and molecular modeling. These studies revealed that selectivity can be achieved in these tetrapodal SCRs by varying the heterocyclic binding group. We found that SCR017 (3-pyrrole), SCR021 (3-pyridine), and SCR022 (2-phenol) bind only to beta-Glc. SCR019 (3-indole) binds only to beta-Man. SCR020 (2-pyridine) binds beta-Man and alpha-Man with a preference to the latter. SCR018 (2-indole) binds alpha-Man and beta-Gal with a preference to the former. The glycan guests bound within their SCR hosts in one of three supramolecular geometries: center-parallel, center-perpendicular, and off-center. Many host-guest combinations formed higher stoichiometry complexes, 2:1 glycan?SCR or 1:2 glycan?SCR, where the former are driven by positive allosteric cooperativity induced by glycan-glycan contacts. |Carbohydrates/*chemical synthesis/chemistry[MESH] |Lectins, C-Type/*chemistry[MESH] |Magnetic Resonance Spectroscopy[MESH] |Mannose Receptor[MESH] |Mannose-Binding Lectins/*chemistry[MESH] |Mannose/*chemical synthesis/chemistry[MESH] |Models, Molecular[MESH] |Molecular Structure[MESH] |Polysaccharides/*chemistry[MESH] |Receptors, Artificial/*chemistry[MESH]Synthesis and Binding of Mannose-Specific Synthetic Carbohydrate Recep(epmc).pdf DeepDyve Pubget Overpricing