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10.1016/j.antiviral.2020.104787

http://scihub22266oqcxt.onion/10.1016/j.antiviral.2020.104787
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32251768!7129059!32251768
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suck abstract from ncbi

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  • The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro #MMPMID32251768
  • Caly L; Druce JD; Catton MG; Jans DA; Wagstaff KM
  • Antiviral Res 2020[Jun]; 178 (ä): 104787 PMID32251768show ga
  • Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 h post infection with SARS-CoV-2 able to effect ~5000-fold reduction in viral RNA at 48 h. Ivermectin therefore warrants further investigation for possible benefits in humans.
  • |*Drug Approval[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/*pharmacology[MESH]
  • |Australia[MESH]
  • |Betacoronavirus/*drug effects/physiology[MESH]
  • |COVID-19[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Coronavirus Infections/drug therapy/*virology[MESH]
  • |Humans[MESH]
  • |Ivermectin/*pharmacology/*therapeutic use[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/drug therapy/*virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Vero Cells[MESH]
  • |Virus Replication/*drug effects[MESH]


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  • suck abstract from ncbi

    104787 ä.178 2020