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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Antiviral+Res 2020 ; 178 (ä): 104787 Nephropedia Template TP
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The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro #MMPMID32251768
Caly L; Druce JD; Catton MG; Jans DA; Wagstaff KM
Antiviral Res 2020[Jun]; 178 (ä): 104787 PMID32251768show ga
Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 h post infection with SARS-CoV-2 able to effect ~5000-fold reduction in viral RNA at 48 h. Ivermectin therefore warrants further investigation for possible benefits in humans.