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10.1016/j.autrev.2020.102537 http://scihub22266oqcxt.onion/10.1016/j.autrev.2020.102537 32251717!7195002!32251717     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autoimmun+Rev 2020 ; 19 (6): 102537 Nephropedia Template TP {{tp|p=32251717|t=2020. The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease |pdf=|usr=}}{{32251717}} gab.com Text The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease JO: Autoimmun Rev http://www.kidney.de/pget.php?&tw=1&pmid=32251717 #FOAvip Severe COVID-19 associated pneumonia patients may exhibit features of systemic hyper-inflammation designated under the umbrella term of macrophage activation syndrome (MAS) or cytokine storm, also known as secondary haemophagocytic lymphohistocytosis (sHLH). This is distinct from HLH associated with immunodeficiency states termed primary HLH -with radically different therapy strategies in both situations. COVID-19 infection with MAS typically occurs in subjects with adult respiratory distress syndrome (ARDS) and historically, non-survival in ARDS was linked to sustained IL-6 and IL-1 elevation. We provide a model for the classification of MAS to stratify the MAS-like presentation in COVID-19 pneumonia and explore the complexities of discerning ARDS from MAS. We discuss the potential impact of timing of anti-cytokine therapy on viral clearance and the impact of such therapy on intra-pulmonary macrophage activation and emergent pulmonary vascular disease. Twit Text FOAVip The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease ????Autoimmun Rev http://www.kidney.de/pget.php?&tw=1&pmid=32251717 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32251717 #FOAvip English Wikipedia <ref>{{Cite pmid|32251717}}</ref> The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease #MMPMID32251717 McGonagle D; Sharif K; O'Regan A; Bridgewood C Autoimmun Rev 2020[Jun]; 19 (6): 102537 PMID32251717show ga Severe COVID-19 associated pneumonia patients may exhibit features of systemic hyper-inflammation designated under the umbrella term of macrophage activation syndrome (MAS) or cytokine storm, also known as secondary haemophagocytic lymphohistocytosis (sHLH). This is distinct from HLH associated with immunodeficiency states termed primary HLH -with radically different therapy strategies in both situations. COVID-19 infection with MAS typically occurs in subjects with adult respiratory distress syndrome (ARDS) and historically, non-survival in ARDS was linked to sustained IL-6 and IL-1 elevation. We provide a model for the classification of MAS to stratify the MAS-like presentation in COVID-19 pneumonia and explore the complexities of discerning ARDS from MAS. We discuss the potential impact of timing of anti-cytokine therapy on viral clearance and the impact of such therapy on intra-pulmonary macrophage activation and emergent pulmonary vascular disease. |Betacoronavirus/immunology/pathogenicity[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/*immunology/pathology[MESH] |Humans[MESH] |Interleukin-1/immunology[MESH] |Interleukin-6/*immunology[MESH] |Lymphohistiocytosis, Hemophagocytic/complications/immunology[MESH] |Macrophage Activation Syndrome/complications/*immunology/pathology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/*immunology/pathology[MESH] |Respiratory Distress Syndrome/complications/*immunology/pathology[MESH]The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneu(epmc).pdf DeepDyve Pubget Overpricing