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  • Macrolide treatment for COVID-19: Will this be the way forward? #MMPMID32249257
  • Ohe M; Shida H; Jodo S; Kusunoki Y; Seki M; Furuya K; Goudarzi H
  • Biosci Trends 2020[May]; 14 (2): 159-160 PMID32249257show ga
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic that has developed in late 2019 and 2020 is a serious threat to human health. With no vaccines or drugs approved for prevention and treatment until now, all efforts at drug design and/or clinical trials of already approved drugs are worthy and creditable. Using structure-based drug selection for identification of SARS-CoV-2 protease inhibitors, old drugs such as macrolides (MAC) were predicted to be effective for COVID-19. Lately, the anti-viral effects of macrolides have attracted considerable attention. Very recently, hydroxychloroquine in combination with azithromycin treatment was reported to be effective for COVID-19. We believe that treatments with macrolides alone or in combination with other drugs are promising and open the possibility of an international strategy to fight this emerging viral infection.
  • |Antiviral Agents/chemistry/pharmacology[MESH]
  • |Betacoronavirus/*drug effects/enzymology/isolation & purification[MESH]
  • |Coronavirus Infections/*drug therapy/epidemiology/virology[MESH]
  • |Humans[MESH]
  • |Macrolides/chemistry/*pharmacology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/epidemiology/virology[MESH]
  • |Protease Inhibitors/chemistry/pharmacology[MESH]
  • |Structure-Activity Relationship[MESH]

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  • suck abstract from ncbi

    159 2.14 2020