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10.1016/j.eururo.2020.03.030

http://scihub22266oqcxt.onion/10.1016/j.eururo.2020.03.030
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32249089!7270372!32249089
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suck abstract from ncbi


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pmid32249089      Eur+Urol 2020 ; 77 (6): 742-747
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  • Identification of Kidney Transplant Recipients with Coronavirus Disease 2019 #MMPMID32249089
  • Zhang H; Chen Y; Yuan Q; Xia QX; Zeng XP; Peng JT; Liu J; Xiao XY; Jiang GS; Xiao HY; Xie LB; Chen J; Liu JL; Xiao X; Su H; Zhang C; Zhang XP; Yang H; Li H; Wang ZD
  • Eur Urol 2020[Jun]; 77 (6): 742-747 PMID32249089show ga
  • Coronavirus disease 2019 (COVID-19) is a novel and lethal infectious disease, posing a threat to global health security. The number of cases has increased rapidly, but no data concerning kidney transplant (KTx) recipients infected with COVID-19 are available. To present the epidemiological, clinical, and therapeutic characteristics of KTx recipients infected with COVID-19, we report on a case series of five patients who were confirmed as having COVID-19 through nucleic acid testing (NAT) from January 1, 2020 to February 28, 2020. The most common symptoms on admission to hospital were fever (five patients, 100%), cough (five patients, 100%), myalgia or fatigue (three patients, 60%), and sputum production (three patients, 60%); serum creatinine or urea nitrogen levels were slightly higher than those before symptom onset. Four patients received a reduced dose of maintenance immunosuppressive therapy during hospitalization. As of March 4, 2020 NAT was negative for COVID-19 in three patients twice in succession, and their computed tomography scans showed improved images. Although greater patient numbers and long-term follow-up data are needed, our series demonstrates that mild COVID-19 infection in KTx recipients can be managed using symptomatic support therapy combined with adjusted maintenance immunosuppressive therapy.
  • |*Clinical Laboratory Techniques[MESH]
  • |*Transplant Recipients[MESH]
  • |Adult[MESH]
  • |Betacoronavirus/genetics/immunology/*isolation & purification[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |China[MESH]
  • |Coronavirus Infections/*diagnosis/therapy/virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunocompromised Host[MESH]
  • |Immunosuppressive Agents/administration & dosage/*adverse effects[MESH]
  • |Kidney Transplantation/*adverse effects[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Opportunistic Infections/*diagnosis/therapy/virology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis/therapy/virology[MESH]
  • |Predictive Value of Tests[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Time Factors[MESH]


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