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10.1007/s40291-020-00460-z http://scihub22266oqcxt.onion/10.1007/s40291-020-00460-z 32248387!7127836!32248387     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Diagn+Ther 2020 ; 24 (3): 251-262 Nephropedia Template TP {{tp|p=32248387|t=2020. Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution |pdf=|usr=}}{{32248387}} gab.com Text Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution JO: Mol Diagn Ther http://www.kidney.de/pget.php?&tw=1&pmid=32248387 #FOAvip This opinion article discusses the increasing attention paid to the role of activating damage-associated molecular patterns (DAMPs) in initiation of inflammatory diseases and suppressing/inhibiting DAMPs (SAMPs) in resolution of inflammatory diseases and, consequently, to the future roles of these novel biomarkers as therapeutic targets and therapeutics. Since controlled production of DAMPs and SAMPs is needed to achieve full homeostatic restoration and repair from tissue injury, only their pathological, not their homeostatic, concentrations should be therapeutically tackled. Therefore, distinct caveats are proposed regarding choosing DAMPs and SAMPs for therapeutic purposes. For example, we discuss the need to a priori identify and define a context-dependent "homeostatic DAMP:SAMP ratio" in each case and a "homeostatic window" of DAMP and SAMP concentrations to guarantee a safe treatment modality to patients. Finally, a few clinical examples of how DAMPs and SAMPs might be used as therapeutic targets or therapeutics in the future are discussed, including inhibition of DAMPs in hyperinflammatory processes (e.g., systemic inflammatory response syndrome, as currently observed in Covid-19), administration of SAMPs in chronic inflammatory diseases, inhibition of SAMPs in hyperresolving processes (e.g., compensatory anti-inflammatory response syndrome), and administration/induction of DAMPs in vaccination procedures and anti-cancer therapy. Twit Text FOAVip Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution ????Mol Diagn Ther http://www.kidney.de/pget.php?&tw=1&pmid=32248387 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32248387 #FOAvip English Wikipedia <ref>{{Cite pmid|32248387}}</ref> Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution #MMPMID32248387 Land WG Mol Diagn Ther 2020[Jun]; 24 (3): 251-262 PMID32248387show ga This opinion article discusses the increasing attention paid to the role of activating damage-associated molecular patterns (DAMPs) in initiation of inflammatory diseases and suppressing/inhibiting DAMPs (SAMPs) in resolution of inflammatory diseases and, consequently, to the future roles of these novel biomarkers as therapeutic targets and therapeutics. Since controlled production of DAMPs and SAMPs is needed to achieve full homeostatic restoration and repair from tissue injury, only their pathological, not their homeostatic, concentrations should be therapeutically tackled. Therefore, distinct caveats are proposed regarding choosing DAMPs and SAMPs for therapeutic purposes. For example, we discuss the need to a priori identify and define a context-dependent "homeostatic DAMP:SAMP ratio" in each case and a "homeostatic window" of DAMP and SAMP concentrations to guarantee a safe treatment modality to patients. Finally, a few clinical examples of how DAMPs and SAMPs might be used as therapeutic targets or therapeutics in the future are discussed, including inhibition of DAMPs in hyperinflammatory processes (e.g., systemic inflammatory response syndrome, as currently observed in Covid-19), administration of SAMPs in chronic inflammatory diseases, inhibition of SAMPs in hyperresolving processes (e.g., compensatory anti-inflammatory response syndrome), and administration/induction of DAMPs in vaccination procedures and anti-cancer therapy. |Biomarkers/blood[MESH] |COVID-19 Drug Treatment[MESH] |Cell-Free Nucleic Acids/blood[MESH] |Chronic Disease[MESH] |Coronavirus Infections/drug therapy[MESH] |HMGB1 Protein/blood[MESH] |Homeostasis[MESH] |Humans[MESH] |Immunity, Innate/drug effects/physiology[MESH] |Inflammation/*drug therapy/*metabolism[MESH] |Molecular Targeted Therapy/*methods[MESH] |Pathogen-Associated Molecular Pattern Molecules/metabolism[MESH] |S100 Proteins/blood[MESH]Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note (epmc).pdf DeepDyve Pubget Overpricing