Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.virusres.2020.197955 http://scihub22266oqcxt.onion/10.1016/j.virusres.2020.197955 32247757!7125813!32247757     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virus+Res 2020 ; 282 (ä): 197955 Nephropedia Template TP {{tp|p=32247757|t=2020. Characterization, pathogenicity and protective efficacy of a cell culture-derived porcine deltacoronavirus |pdf=|usr=}}{{32247757}} gab.com Text Characterization, pathogenicity and protective efficacy of a cell culture-derived porcine deltacoronavirus JO: Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=32247757 #FOAvip Porcine deltacoronavirus (PDCoV) is a novel swine enteropathogenic coronavirus that causes acute diarrhea, vomiting, dehydration and mortality in neonatal piglets, resulting in significant economic losses to the pig industry. However, there is currently little information on vaccine studies and commercially available vaccines for PDCoV. Hence, herein, a PDCoV strain, CH/XJYN/2016, was successfully isolated and serially propagated in vitro, and its biological characteristics were determined. Compared to that of previously reported and recently isolated PDCoV strains from China and the United States, the S gene of the CH/XJYN/2016 strain contains novel mutations. Infection studies revealed that CH/XJYN/2016 is pathogenic to suckling piglets and conventional weaned pigs. In addition, the median pig diarrhea dose (PDD(50)) of PDCoV in conventional weaned pigs was determined (2.0 log(10)PDD(50)/3?mL). Furthermore, an inactivated cell-adapted CH/XJYN/2016-based vaccine candidate was developed with different adjuvants. Compared with nonvaccinated pigs, conventional weaned pigs given the inactivated vaccine developed a potent humoral immune response and showed no clinical signs or viral shedding after challenge, indicating a potent protective effect of the vaccine against PDCoV infection. Therefore, the PDCoV vaccine developed in this study is a promising vaccine candidate that can be used for the control of PDCoV infection in pigs. Twit Text FOAVip Characterization, pathogenicity and protective efficacy of a cell culture-derived porcine deltacoronavirus ????Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=32247757 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32247757 #FOAvip English Wikipedia <ref>{{Cite pmid|32247757}}</ref> Characterization, pathogenicity and protective efficacy of a cell culture-derived porcine deltacoronavirus #MMPMID32247757 Gao X; Zhao D; Zhou P; Zhang L; Li M; Li W; Zhang Y; Wang Y; Liu X Virus Res 2020[Jun]; 282 (ä): 197955 PMID32247757show ga Porcine deltacoronavirus (PDCoV) is a novel swine enteropathogenic coronavirus that causes acute diarrhea, vomiting, dehydration and mortality in neonatal piglets, resulting in significant economic losses to the pig industry. However, there is currently little information on vaccine studies and commercially available vaccines for PDCoV. Hence, herein, a PDCoV strain, CH/XJYN/2016, was successfully isolated and serially propagated in vitro, and its biological characteristics were determined. Compared to that of previously reported and recently isolated PDCoV strains from China and the United States, the S gene of the CH/XJYN/2016 strain contains novel mutations. Infection studies revealed that CH/XJYN/2016 is pathogenic to suckling piglets and conventional weaned pigs. In addition, the median pig diarrhea dose (PDD(50)) of PDCoV in conventional weaned pigs was determined (2.0 log(10)PDD(50)/3?mL). Furthermore, an inactivated cell-adapted CH/XJYN/2016-based vaccine candidate was developed with different adjuvants. Compared with nonvaccinated pigs, conventional weaned pigs given the inactivated vaccine developed a potent humoral immune response and showed no clinical signs or viral shedding after challenge, indicating a potent protective effect of the vaccine against PDCoV infection. Therefore, the PDCoV vaccine developed in this study is a promising vaccine candidate that can be used for the control of PDCoV infection in pigs. |Animals[MESH] |Cell Line[MESH] |Coronavirus Infections/immunology/prevention & control/*veterinary/virology[MESH] |Coronavirus/classification/genetics/*immunology/*pathogenicity[MESH] |Genome, Viral/genetics[MESH] |Immunogenicity, Vaccine[MESH] |Mutation[MESH] |Phylogeny[MESH] |Serial Passage[MESH] |Spike Glycoprotein, Coronavirus/genetics[MESH] |Swine[MESH] |Swine Diseases/immunology/prevention & control/*virology[MESH] |Vaccination/veterinary[MESH] |Vaccines, Inactivated/immunology[MESH]Characterization, pathogenicity and protective efficacy of a cell cult(epmc).pdf DeepDyve Pubget Overpricing