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10.1016/j.ijid.2020.03.071

http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.03.071
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suck abstract from ncbi


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pmid32247050      Int+J+Infect+Dis 2020 ; 94 (ä): 119-124
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  • Insight into 2019 novel coronavirus - An updated interim review and lessons from SARS-CoV and MERS-CoV #MMPMID32247050
  • Xie M; Chen Q
  • Int J Infect Dis 2020[May]; 94 (ä): 119-124 PMID32247050show ga
  • BACKGROUND: The rapid spread of the coronavirus disease 2019 (COVID-19), caused by a zoonotic beta-coronavirus entitled 2019 novel coronavirus (2019-nCoV), has become a global threat. Awareness of the biological features of 2019-nCoV should be updated in time and needs to be comprehensively summarized to help optimize control measures and make therapeutic decisions. METHODS: Based on recently published literature, official documents and selected up-to-date preprint studies, we reviewed the virology and origin, epidemiology, clinical manifestations, pathology and treatment of 2019-nCoV infection, in comparison with severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) infection. RESULTS: The genome of 2019-nCoV partially resembled SARS-CoV and MERS-CoV, and indicated a bat origin. The COVID-19 generally had a high reproductive number, a long incubation period, a short serial interval and a low case fatality rate (much higher in patients with comorbidities) than SARS and MERS. Clinical presentation and pathology of COVID-19 greatly resembled SARS and MERS, with less upper respiratory and gastrointestinal symptoms, and more exudative lesions in post-mortems. Potential treatments included remdesivir, chloroquine, tocilizumab, convalescent plasma and vaccine immunization (when possible). CONCLUSION: The initial experience from the current pandemic and lessons from the previous two pandemics can help improve future preparedness plans and combat disease progression.
  • |*Betacoronavirus[MESH]
  • |*Coronavirus Infections/therapy[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/therapy[MESH]
  • |Animals[MESH]
  • |COVID-19[MESH]
  • |Humans[MESH]
  • |Middle East Respiratory Syndrome Coronavirus[MESH]
  • |SARS-CoV-2[MESH]


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