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10.15252/embj.20105114 http://scihub22266oqcxt.onion/10.15252/embj.20105114 32246845!7232010!32246845     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2020 ; 39 (10): e105114 Nephropedia Template TP {{tp|p=32246845|t=2020. SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells |pdf=|usr=}}{{32246845}} gab.com Text SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=32246845 #FOAvip The SARS-CoV-2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection and replication. SARS-CoV-2 was reported to enter cells via binding to ACE2, followed by its priming by TMPRSS2. Here, we investigate ACE2 and TMPRSS2 expression levels and their distribution across cell types in lung tissue (twelve donors, 39,778 cells) and in cells derived from subsegmental bronchial branches (four donors, 17,521 cells) by single nuclei and single cell RNA sequencing, respectively. While TMPRSS2 is strongly expressed in both tissues, in the subsegmental bronchial branches ACE2 is predominantly expressed in a transient secretory cell type. Interestingly, these transiently differentiating cells show an enrichment for pathways related to RHO GTPase function and viral processes suggesting increased vulnerability for SARS-CoV-2 infection. Our data provide a rich resource for future investigations of COVID-19 infection and pathogenesis. Twit Text FOAVip SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=32246845 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32246845 #FOAvip English Wikipedia <ref>{{Cite pmid|32246845}}</ref> SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells #MMPMID32246845 Lukassen S; Chua RL; Trefzer T; Kahn NC; Schneider MA; Muley T; Winter H; Meister M; Veith C; Boots AW; Hennig BP; Kreuter M; Conrad C; Eils R EMBO J 2020[May]; 39 (10): e105114 PMID32246845show ga The SARS-CoV-2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection and replication. SARS-CoV-2 was reported to enter cells via binding to ACE2, followed by its priming by TMPRSS2. Here, we investigate ACE2 and TMPRSS2 expression levels and their distribution across cell types in lung tissue (twelve donors, 39,778 cells) and in cells derived from subsegmental bronchial branches (four donors, 17,521 cells) by single nuclei and single cell RNA sequencing, respectively. While TMPRSS2 is strongly expressed in both tissues, in the subsegmental bronchial branches ACE2 is predominantly expressed in a transient secretory cell type. Interestingly, these transiently differentiating cells show an enrichment for pathways related to RHO GTPase function and viral processes suggesting increased vulnerability for SARS-CoV-2 infection. Our data provide a rich resource for future investigations of COVID-19 infection and pathogenesis. |*Gene Expression[MESH] |*Single-Cell Analysis[MESH] |Adult[MESH] |Aging[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Bronchi/*cytology/metabolism[MESH] |COVID-19[MESH] |Cells, Cultured[MESH] |Chronic Disease/epidemiology[MESH] |Coronavirus Infections/genetics[MESH] |Epithelial Cells/metabolism[MESH] |Female[MESH] |Gene Expression Profiling[MESH] |Germany[MESH] |Goblet Cells/metabolism[MESH] |Humans[MESH] |Lung/*cytology/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*genetics[MESH] |Pneumonia, Viral/genetics[MESH] |Reference Standards[MESH] |Sequence Analysis, RNA[MESH] |Serine Endopeptidases/*genetics[MESH] |Sex Characteristics[MESH] |Smoking[MESH]SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronch(epmc).pdf DeepDyve Pubget Overpricing