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10.3390/jcm9040982 http://scihub22266oqcxt.onion/10.3390/jcm9040982 32244779!7230814!32244779     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Med 2020 ; 9 (4): ä Nephropedia Template TP {{tp|p=32244779|t=2020. Master Regulator Analysis of the SARS-CoV-2/Human Interactome |pdf=|usr=}}{{32244779}} gab.com Text Master Regulator Analysis of the SARS-CoV-2/Human Interactome JO: J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=32244779 #FOAvip The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus. Twit Text FOAVip Master Regulator Analysis of the SARS-CoV-2/Human Interactome ????J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=32244779 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32244779 #FOAvip English Wikipedia <ref>{{Cite pmid|32244779}}</ref> Master Regulator Analysis of the SARS-CoV-2/Human Interactome #MMPMID32244779 Guzzi PH; Mercatelli D; Ceraolo C; Giorgi FM J Clin Med 2020[Apr]; 9 (4): ä PMID32244779show ga The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus. äMaster Regulator Analysis of the SARS-CoV-2/Human Interactome (epmc).pdf DeepDyve Pubget Overpricing