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  • COVID-19 in posttransplant patients-report of 2 cases #MMPMID32243697
  • Huang J; Lin H; Wu Y; Fang Y; Kumar R; Chen G; Lin S
  • Am J Transplant 2020[Jul]; 20 (7): 1879-1881 PMID32243697show ga
  • Coronavirus Disease 2019 (COVID-19) has become a pandemic since March 2020. We describe here 2 cases of COVID-19 infection in a posttransplant setting. First one is a 59-year-old renal transplant recipient; the second is a 51-year-old allogeneic bone marrow transplant recipient. Both patients were on immunosuppressant therapy and had stable graft function before COVID-19 infection. After the diagnosis of COVID-19, immunosuppressive agents were discontinued and methylprednisolone with prophylactic antibiotics were initiated, however, the lung injury progressed. The T cells were extremely low in both patients after infection. Both patients died despite the maximal mechanical ventilatory support. Therefore, the prognosis of COVID-19 pneumonia following transplantation is not optimistic and remains guarded. Lower T cell count may be a surrogate for poor outcome.
  • |*Bone Marrow Transplantation[MESH]
  • |*Kidney Transplantation[MESH]
  • |*Transplant Recipients[MESH]
  • |Anti-Bacterial Agents/administration & dosage[MESH]
  • |Bacterial Infections/complications[MESH]
  • |COVID-19[MESH]
  • |China[MESH]
  • |Coronavirus Infections/*complications/diagnosis/therapy[MESH]
  • |Cross Infection/complications[MESH]
  • |Fatal Outcome[MESH]
  • |Humans[MESH]
  • |Immunosuppressive Agents/administration & dosage[MESH]
  • |Kidney Failure, Chronic/*complications/surgery[MESH]
  • |Leukemia, Myeloid, Acute/*complications/therapy[MESH]
  • |Male[MESH]
  • |Methylprednisolone/administration & dosage[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/diagnosis/therapy[MESH]
  • |Postoperative Complications[MESH]
  • |Prognosis[MESH]
  • |Respiration, Artificial[MESH]
  • |T-Lymphocytes/cytology[MESH]

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  • suck abstract from ncbi

    1879 7.20 2020