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  • A familial cluster, including a kidney transplant recipient, of Coronavirus Disease 2019 (COVID-19) in Wuhan, China #MMPMID32243690
  • Chen S; Yin Q; Shi H; Du D; Chang S; Ni L; Qiu H; Chen Z; Zhang J; Zhang W
  • Am J Transplant 2020[Jul]; 20 (7): 1869-1874 PMID32243690show ga
  • In December 2019, an outbreak of COVID-19 occurred in Wuhan, China, and spread to the whole of China and to multiple countries worldwide. Unlike SARS and MERS, where secondary transmission mostly occurred in hospital settings, COVID-19 transmission occurs in large numbers within families. Herein we report three cases of a familial cluster with one family member being a kidney transplant recipient. The initial clinical symptoms of COVID-19 in these three patients were the same, but their progression was different. Based on the severity of clinical symptoms, chest computer tomography findings and SARS-Cov-2 RNA test results, we admitted the husband to the respiratory intensive care unit (RICU) and used a treatment consisting of immunosuppressant reduction/cessation and low dose methylprednisolone-based therapy, and his wife to the respiratory isolation ward. In contrast, the son received in-home isolation and home-based care. All three family members made a full recovery.
  • |*Kidney Transplantation[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Coronavirus Infections/*complications/diagnosis/*therapy[MESH]
  • |Disease Outbreaks[MESH]
  • |Disease Progression[MESH]
  • |Family Health[MESH]
  • |Female[MESH]
  • |Glomerulonephritis/complications/*surgery[MESH]
  • |Humans[MESH]
  • |Immunosuppressive Agents/administration & dosage/therapeutic use[MESH]
  • |Intensive Care Units[MESH]
  • |Kidney Failure, Chronic/complications/*surgery[MESH]
  • |Male[MESH]
  • |Methylprednisolone/administration & dosage[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/diagnosis/*therapy[MESH]
  • |Radiography, Thoracic[MESH]
  • |SARS-CoV-2[MESH]
  • |Tomography, X-Ray Computed[MESH]
  • |Young Adult[MESH]

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  • suck abstract from ncbi

    1869 7.20 2020