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10.1111/liv.14449

http://scihub22266oqcxt.onion/10.1111/liv.14449
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32239591!7228333!32239591
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suck abstract from ncbi


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pmid32239591      Liver+Int 2020 ; 40 (6): 1321-1326
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  • Clinical characteristics of non-ICU hospitalized patients with coronavirus disease 2019 and liver injury: A retrospective study #MMPMID32239591
  • Xie H; Zhao J; Lian N; Lin S; Xie Q; Zhuo H
  • Liver Int 2020[Jun]; 40 (6): 1321-1326 PMID32239591show ga
  • BACKGROUND & AIMS: Coronavirus disease 2019 (COVID-19) has raised world concern for global epidemic since December, 2019. Limited data are available for liver function in COVID-19 patients. We aimed to investigate the risk factors related to liver injury in the COVID-19 patients. METHODS: A retrospective study was performed in non-ICU Ward at Jinyintan Hospital from February 2, 2020 to February 23, 2020. Consecutively confirmed COVID-19 discharged cases were enrolled. The clinical characteristics of patients with liver injury and without liver injury were compared. RESULTS: A total of 79 COVID-19 patients were included. 31.6%, 35.4% and 5.1% COVID-19 patients had elevated levels of alanine transaminase (ALT), aspartate aminotransferase (AST) and bilirubin respectively. Median value of ALT, AST and bilirubin for entire cohort was 36.5 (17.5 ~ 71.5) U/L, 34.5 (25.3 ~ 55.3) U/L and 12.7 (8.1 ~ 15.4) mmol/L respectively. There were no significant differences in age, previous medical history and symptoms between the two groups. Males were more likely to have liver injury when infected with COVID-19 (P < .05); compared with patients without liver injury, patients with liver injury had increased levels of white blood cell counts, neutrophils, CRP and CT score (P < .05) and had a longer length of stay (P < .05). Logistic regression analyses suggested that the extent of pulmonary lesions on CT was a predictor of liver function damage (P < .05). CONCLUSIONS: Liver injury is common in non-ICU hospitalized COVID-19 patients. It may be related to systemic inflammation. Intense monitoring and evaluation of liver function in patients with severe pulmonary imaging lesions should be considered.
  • |*Coronavirus Infections/blood/complications/diagnosis/epidemiology[MESH]
  • |*Liver Diseases/blood/diagnosis/epidemiology/etiology[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/blood/complications/diagnosis/epidemiology/etiology[MESH]
  • |Alanine Transaminase/blood[MESH]
  • |Aspartate Aminotransferases/blood[MESH]
  • |Betacoronavirus/*isolation & purification[MESH]
  • |Bilirubin/blood[MESH]
  • |COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Female[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Liver Function Tests/*methods[MESH]
  • |Lung/diagnostic imaging[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Prevalence[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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