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10.1038/s41551-020-0540-y http://scihub22266oqcxt.onion/10.1038/s41551-020-0540-y 32231314!7197249!32231314     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Biomed+Eng 2020 ; 4 (7): 704-716 Nephropedia Template TP {{tp|p=32231314|t=2020. Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids |pdf=|usr=}}{{32231314}} gab.com Text Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids JO: Nat Biomed Eng http://www.kidney.de/pget.php?&tw=1&pmid=32231314 #FOAvip Strategies for selectively imaging and delivering drugs to tumours typically leverage differentially upregulated surface molecules on cancer cells. Here, we show that intravenously injected carbon quantum dots, functionalized with multiple paired alpha-carboxyl and amino groups that bind to the large neutral amino acid transporter 1 (which is expressed in most tumours), selectively accumulate in human tumour xenografts in mice and in an orthotopic mouse model of human glioma. The functionalized quantum dots, which structurally mimic large amino acids and can be loaded with aromatic drugs through pi-pi stacking interactions, enabled-in the absence of detectable toxicity-near-infrared fluorescence and photoacoustic imaging of the tumours and a reduction in tumour burden after the targeted delivery of chemotherapeutics to the tumours. The versatility of functionalization and high tumour selectivity of the quantum dots make them broadly suitable for tumour-specific imaging and drug delivery. Twit Text FOAVip Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids ????Nat Biomed Eng http://www.kidney.de/pget.php?&tw=1&pmid=32231314 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32231314 #FOAvip English Wikipedia <ref>{{Cite pmid|32231314}}</ref> Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids #MMPMID32231314 Li S; Su W; Wu H; Yuan T; Yuan C; Liu J; Deng G; Gao X; Chen Z; Bao Y; Yuan F; Zhou S; Tan H; Li Y; Li X; Fan L; Zhu J; Chen AT; Liu F; Zhou Y; Li M; Zhai X; Zhou J Nat Biomed Eng 2020[Jul]; 4 (7): 704-716 PMID32231314show ga Strategies for selectively imaging and delivering drugs to tumours typically leverage differentially upregulated surface molecules on cancer cells. Here, we show that intravenously injected carbon quantum dots, functionalized with multiple paired alpha-carboxyl and amino groups that bind to the large neutral amino acid transporter 1 (which is expressed in most tumours), selectively accumulate in human tumour xenografts in mice and in an orthotopic mouse model of human glioma. The functionalized quantum dots, which structurally mimic large amino acids and can be loaded with aromatic drugs through pi-pi stacking interactions, enabled-in the absence of detectable toxicity-near-infrared fluorescence and photoacoustic imaging of the tumours and a reduction in tumour burden after the targeted delivery of chemotherapeutics to the tumours. The versatility of functionalization and high tumour selectivity of the quantum dots make them broadly suitable for tumour-specific imaging and drug delivery. |Amino Acids/*chemistry[MESH] |Animals[MESH] |Biomedical Engineering[MESH] |Brain Neoplasms/diagnostic imaging/drug therapy[MESH] |Carbon/*chemistry[MESH] |Cell Line, Tumor[MESH] |Drug Delivery Systems/*methods[MESH] |Female[MESH] |Humans[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Nude[MESH] |Quantum Dots/*chemistry[MESH]Targeted tumour theranostics in mice via carbon quantum dots structura(epmc).pdf DeepDyve Pubget Overpricing