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10.1016/j.ejrad.2020.108961

http://scihub22266oqcxt.onion/10.1016/j.ejrad.2020.108961
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32229322!7102545!32229322
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suck abstract from ncbi


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pmid32229322      Eur+J+Radiol 2020 ; 126 (ä): 108961
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  • Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT? #MMPMID32229322
  • Long C; Xu H; Shen Q; Zhang X; Fan B; Wang C; Zeng B; Li Z; Li X; Li H
  • Eur J Radiol 2020[May]; 126 (ä): 108961 PMID32229322show ga
  • PURPOSE: To evaluate the diagnostic value of computed tomography (CT) and real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) for COVID-19 pneumonia. METHODS: This retrospective study included all patients with COVID-19 pneumonia suspicion, who were examined by both CT and rRT-PCR at initial presentation. The sensitivities of both tests were then compared. For patients with a final confirmed diagnosis, clinical and laboratory data, in addition to CT imaging findings were evaluated. RESULTS: A total of 36 patients were finally diagnosed with COVID-19 pneumonia. Thirty-five patients had abnormal CT findings at presentation, whereas one patient had a normal CT. Using rRT-PCR, 30 patients were tested positive, with 6 cases initially missed. Amongst these 6 patients, 3 became positive in the second rRT-PCR assay(after 2 days, 2 days and 3 days respectively), and the other 3 became positive only in the third round of rRT-PCR tests(after 5 days, 6 days and 8 days respectively). At presentation, CT sensitivity was therefore 97.2%, whereas the sensitivity of initial rRT-PCR was only 83.3%. CONCLUSION: rRT-PCR may produce initial false negative results. We suggest that patients with typical CT findings but negative rRT-PCR results should be isolated, and rRT-PCR should be repeated to avoid misdiagnosis.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Betacoronavirus/*genetics[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Clinical Laboratory Techniques/methods[MESH]
  • |Coronavirus Infections/*diagnosis[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis[MESH]
  • |Real-Time Polymerase Chain Reaction[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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