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10.1093/cid/ciaa271

http://scihub22266oqcxt.onion/10.1093/cid/ciaa271
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32227091!7184369!32227091
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suck abstract from ncbi


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pmid32227091      Clin+Infect+Dis 2020 ; 71 (15): 723-731
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  • Novel Coronavirus Disease 2019 (COVID-19) Pneumonia Progression Course in 17 Discharged Patients: Comparison of Clinical and Thin-Section Computed Tomography Features During Recovery #MMPMID32227091
  • Han X; Cao Y; Jiang N; Chen Y; Alwalid O; Zhang X; Gu J; Dai M; Liu J; Zhu W; Zheng C; Shi H
  • Clin Infect Dis 2020[Jul]; 71 (15): 723-731 PMID32227091show ga
  • BACKGROUND: Our objective was to retrospectively analyze the evolution of clinical features and thin-section computed tomography (CT) imaging of novel coronavirus disease 2019 (COVID-19) pneumonia in 17 discharged patients. METHODS: Serial thin-section CT scans of 17 discharged patients with COVID-19 were obtained during recovery. Longitudinal changes of clinical parameters and a CT pattern were documented in all patients during the 4 weeks after admission. A CT score was used to evaluate the extent of the disease. RESULTS: There were marked improvements of fever, lymphocyte counts, C-reactive proteins, and erythrocyte sedimentation rates within the first 2 weeks after admission. However, the mean CT score rapidly increased from the first to the third week, with a top score of 8.2 obtained in the second week. During the first week, the main CT pattern was ground-glass opacities (GGO; 76.5%). The frequency of GGO (52.9%) decreased in the second week. Consolidation and mixed patterns (47.0%) were noted in the second week. Thereafter, consolidations generally dissipated into GGO, and the frequency of GGO increased in the third week (76.5%) and fourth week (71.4%). Opacities were mainly located in the peripheral (76.5%) and subpleural (47.1%) zones of the lungs; they presented as focal (35.3%) or multifocal (29.4%) in the first week and became more diffuse in the second (47.1%) and third weeks (58.8%), then showed a reduced extent in fourth week (50%). CONCLUSIONS: The progression course of the CT pattern was later than the progression of the clinical parameters within the first 2 weeks after admission; however, there were synchronized improvements in both the clinical and radiologic features in the fourth week.
  • |Adult[MESH]
  • |Betacoronavirus/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*pathology/virology[MESH]
  • |Disease Progression[MESH]
  • |Female[MESH]
  • |Fever/pathology/virology[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Lung/pathology/virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Patient Discharge[MESH]
  • |Pneumonia, Viral/*pathology/virology[MESH]
  • |Pneumonia/*pathology/virology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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