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10.1093/cvr/cvaa078 http://scihub22266oqcxt.onion/10.1093/cvr/cvaa078 32227090!7184507!32227090     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cardiovasc+Res 2020 ; 116 (6): 1097-1100 Nephropedia Template TP {{tp|p=32227090|t=2020. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2 |pdf=|usr=}}{{32227090}} gab.com Text The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2 JO: Cardiovasc Res http://www.kidney.de/pget.php?&tw=1&pmid=32227090 #FOAvip A new type of pneumonia caused by a novel coronavirus SARS-CoV-2 outbreaks recently in China and spreads into many other countries. This disease, named as COVID-19, is similar to patients infected by SARS-CoV and MERS-CoV, and nearly 20% of patients developed severe condition. Cardiac injury is a prevalent complication of severe patients, exacerbating the disease severity in coronavirus disease 2019 (COVID-19) patients. Angiotensin-converting enzyme 2 (ACE2), the key host cellular receptor of SARS-CoV-2, has been identified in multiple organs, but its cellular distribution in human heart is not illuminated clearly. This study performed the first state-of-art single cell atlas of adult human heart, and revealed that pericytes with high expression of ACE2 might act as the target cardiac cell of SARS-CoV-2. The pericytes injury due to virus infection may result in capillary endothelial cells dysfunction, inducing microvascular dysfunction. And patients with basic heart failure disease showed increased ACE2 expression at both mRNA and protein levels, meaning that if infected by the virus these patients may have higher risk of heart attack and critically ill condition. The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2. Twit Text FOAVip The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2 ????Cardiovasc Res http://www.kidney.de/pget.php?&tw=1&pmid=32227090 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32227090 #FOAvip English Wikipedia <ref>{{Cite pmid|32227090}}</ref> The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2 #MMPMID32227090 Chen L; Li X; Chen M; Feng Y; Xiong C Cardiovasc Res 2020[May]; 116 (6): 1097-1100 PMID32227090show ga A new type of pneumonia caused by a novel coronavirus SARS-CoV-2 outbreaks recently in China and spreads into many other countries. This disease, named as COVID-19, is similar to patients infected by SARS-CoV and MERS-CoV, and nearly 20% of patients developed severe condition. Cardiac injury is a prevalent complication of severe patients, exacerbating the disease severity in coronavirus disease 2019 (COVID-19) patients. Angiotensin-converting enzyme 2 (ACE2), the key host cellular receptor of SARS-CoV-2, has been identified in multiple organs, but its cellular distribution in human heart is not illuminated clearly. This study performed the first state-of-art single cell atlas of adult human heart, and revealed that pericytes with high expression of ACE2 might act as the target cardiac cell of SARS-CoV-2. The pericytes injury due to virus infection may result in capillary endothelial cells dysfunction, inducing microvascular dysfunction. And patients with basic heart failure disease showed increased ACE2 expression at both mRNA and protein levels, meaning that if infected by the virus these patients may have higher risk of heart attack and critically ill condition. The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2. |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/metabolism/*physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/virology[MESH] |Gene Expression[MESH] |Gene Expression Profiling[MESH] |Heart Diseases/*etiology[MESH] |Heart/virology[MESH] |Humans[MESH] |Myocardium/*enzymology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics/*metabolism[MESH] |Pericytes/*enzymology/virology[MESH] |Pneumonia, Viral/*complications/virology[MESH] |Receptors, Coronavirus[MESH] |Receptors, Virus/genetics/metabolism[MESH] |SARS-CoV-2[MESH]The ACE2 expression in human heart indicates new potential mechanism o(epmc).pdf DeepDyve Pubget Overpricing