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10.1002/jmv.25785 http://scihub22266oqcxt.onion/10.1002/jmv.25785 32221983!7317908!32221983     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2020 ; 92 (7): 726-730 Nephropedia Template TP {{tp|p=32221983|t=2020. Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19 |pdf=|usr=}}{{32221983}} gab.com Text Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19 JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32221983 #FOAvip This article reviews the correlation between angiotensin-converting enzyme 2 (ACE2) and severe risk factors for coronavirus disease 2019 (COVID-19) and the possible mechanisms. ACE2 is a crucial component of the renin-angiotensin system (RAS). The classical RAS ACE-Ang II-AT1R regulatory axis and the ACE2-Ang 1-7-MasR counter-regulatory axis play an essential role in maintaining homeostasis in humans. ACE2 is widely distributed in the heart, kidneys, lungs, and testes. ACE2 antagonizes the activation of the classical RAS system and protects against organ damage, protecting against hypertension, diabetes, and cardiovascular disease. Similar to SARS-CoV, SARS-CoV-2 also uses the ACE2 receptor to invade human alveolar epithelial cells. Acute respiratory distress syndrome (ARDS) is a clinical high-mortality disease, and ACE2 has a protective effect on this type of acute lung injury. Current research shows that the poor prognosis of patients with COVID-19 is related to factors such as sex (male), age (>60 years), underlying diseases (hypertension, diabetes, and cardiovascular disease), secondary ARDS, and other relevant factors. Because of these protective effects of ACE2 on chronic underlying diseases and ARDS, the development of spike protein-based vaccine and drugs enhancing ACE2 activity may become one of the most promising approaches for the treatment of COVID-19 in the future. Twit Text FOAVip Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19 ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32221983 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32221983 #FOAvip English Wikipedia <ref>{{Cite pmid|32221983}}</ref> Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19 #MMPMID32221983 Cheng H; Wang Y; Wang GQ J Med Virol 2020[Jul]; 92 (7): 726-730 PMID32221983show ga This article reviews the correlation between angiotensin-converting enzyme 2 (ACE2) and severe risk factors for coronavirus disease 2019 (COVID-19) and the possible mechanisms. ACE2 is a crucial component of the renin-angiotensin system (RAS). The classical RAS ACE-Ang II-AT1R regulatory axis and the ACE2-Ang 1-7-MasR counter-regulatory axis play an essential role in maintaining homeostasis in humans. ACE2 is widely distributed in the heart, kidneys, lungs, and testes. ACE2 antagonizes the activation of the classical RAS system and protects against organ damage, protecting against hypertension, diabetes, and cardiovascular disease. Similar to SARS-CoV, SARS-CoV-2 also uses the ACE2 receptor to invade human alveolar epithelial cells. Acute respiratory distress syndrome (ARDS) is a clinical high-mortality disease, and ACE2 has a protective effect on this type of acute lung injury. Current research shows that the poor prognosis of patients with COVID-19 is related to factors such as sex (male), age (>60 years), underlying diseases (hypertension, diabetes, and cardiovascular disease), secondary ARDS, and other relevant factors. Because of these protective effects of ACE2 on chronic underlying diseases and ARDS, the development of spike protein-based vaccine and drugs enhancing ACE2 activity may become one of the most promising approaches for the treatment of COVID-19 in the future. |*Pandemics[MESH] |Age Factors[MESH] |Angiotensin I/therapeutic use[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Angiotensin-Converting Enzyme Inhibitors/therapeutic use[MESH] |Antiviral Agents/therapeutic use[MESH] |Betacoronavirus/drug effects/*pathogenicity[MESH] |COVID-19[MESH] |Cardiovascular Diseases/complications/drug therapy/epidemiology/*genetics[MESH] |Coronavirus Infections/complications/drug therapy/epidemiology/*genetics[MESH] |Gene Expression Regulation[MESH] |Host-Pathogen Interactions/genetics[MESH] |Humans[MESH] |Peptide Fragments/therapeutic use[MESH] |Peptidyl-Dipeptidase A/*genetics/metabolism[MESH] |Pneumonia, Viral/complications/drug therapy/epidemiology/*genetics[MESH] |Prognosis[MESH] |Proto-Oncogene Mas[MESH] |Receptor, Angiotensin, Type 1/genetics/metabolism[MESH] |Receptors, Virus/genetics/metabolism[MESH] |SARS-CoV-2[MESH] |Sex Factors[MESH] |Signal Transduction[MESH]Organ-protective effect of angiotensin-converting enzyme 2 and its eff(epmc).pdf DeepDyve Pubget Overpricing