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10.1038/s41467-020-15562-9

http://scihub22266oqcxt.onion/10.1038/s41467-020-15562-9
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32221306!7100515!32221306
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suck abstract from ncbi


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pmid32221306      Nat+Commun 2020 ; 11 (1): 1620
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  • Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV #MMPMID32221306
  • Ou X; Liu Y; Lei X; Li P; Mi D; Ren L; Guo L; Guo R; Chen T; Hu J; Xiang Z; Mu Z; Chen X; Chen J; Hu K; Jin Q; Wang J; Qian Z
  • Nat Commun 2020[Mar]; 11 (1): 1620 PMID32221306show ga
  • Since 2002, beta coronaviruses (CoV) have caused three zoonotic outbreaks, SARS-CoV in 2002-2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late 2019. However, little is currently known about the biology of SARS-CoV-2. Here, using SARS-CoV-2 S protein pseudovirus system, we confirm that human angiotensin converting enzyme 2 (hACE2) is the receptor for SARS-CoV-2, find that SARS-CoV-2 enters 293/hACE2 cells mainly through endocytosis, that PIKfyve, TPC2, and cathepsin L are critical for entry, and that SARS-CoV-2 S protein is less stable than SARS-CoV S. Polyclonal anti-SARS S1 antibodies T62 inhibit entry of SARS-CoV S but not SARS-CoV-2 S pseudovirions. Further studies using recovered SARS and COVID-19 patients' sera show limited cross-neutralization, suggesting that recovery from one infection might not protect against the other. Our results present potential targets for development of drugs and vaccines for SARS-CoV-2.
  • |*Virus Internalization[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Antibodies, Viral/*immunology[MESH]
  • |Betacoronavirus/chemistry/immunology/*physiology[MESH]
  • |Broadly Neutralizing Antibodies/*immunology[MESH]
  • |COVID-19[MESH]
  • |Calcium Channels/metabolism[MESH]
  • |Cathepsin L/metabolism[MESH]
  • |Cathepsins/antagonists & inhibitors/metabolism[MESH]
  • |Cell Fusion[MESH]
  • |Coronavirus Infections/immunology[MESH]
  • |Cross Reactions[MESH]
  • |Endocytosis[MESH]
  • |Giant Cells/physiology[MESH]
  • |HEK293 Cells[MESH]
  • |Humans[MESH]
  • |Neutralization Tests[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/metabolism[MESH]
  • |Phosphatidylinositol 3-Kinases/metabolism[MESH]
  • |Pneumonia, Viral/immunology[MESH]
  • |Protein Domains[MESH]
  • |Protein Multimerization[MESH]
  • |Receptors, Virus/metabolism[MESH]
  • |SARS-CoV-2[MESH]
  • |Severe Acute Respiratory Syndrome/immunology[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/immunology[MESH]
  • |Spike Glycoprotein, Coronavirus/chemistry/*immunology/*metabolism[MESH]


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