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  • Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins #MMPMID32218527
  • Lam TT; Jia N; Zhang YW; Shum MH; Jiang JF; Zhu HC; Tong YG; Shi YX; Ni XB; Liao YS; Li WJ; Jiang BG; Wei W; Yuan TT; Zheng K; Cui XM; Li J; Pei GQ; Qiang X; Cheung WY; Li LF; Sun FF; Qin S; Huang JC; Leung GM; Holmes EC; Hu YL; Guan Y; Cao WC
  • Nature 2020[Jul]; 583 (7815): 282-285 PMID32218527show ga
  • The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-2(1). This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection(2). Although bats are probable reservoir hosts for SARS-CoV-2, the identity of any intermediate host that may have facilitated transfer to humans is unknown. Here we report the identification of SARS-CoV-2-related coronaviruses in Malayan pangolins (Manis javanica) seized in anti-smuggling operations in southern China. Metagenomic sequencing identified pangolin-associated coronaviruses that belong to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2. The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of new coronaviruses and should be removed from wet markets to prevent zoonotic transmission.
  • |*Evolution, Molecular[MESH]
  • |*Sequence Homology, Nucleic Acid[MESH]
  • |Amino Acid Sequence[MESH]
  • |Animals[MESH]
  • |Betacoronavirus/chemistry/classification/*genetics/*isolation & purification[MESH]
  • |COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Chiroptera/virology[MESH]
  • |Coronavirus Infections/epidemiology/transmission/virology[MESH]
  • |Disease Reservoirs/virology[MESH]
  • |Eutheria/*virology[MESH]
  • |Genome, Viral/*genetics[MESH]
  • |Genomics[MESH]
  • |Humans[MESH]
  • |Malaysia[MESH]
  • |Pandemics[MESH]
  • |Phylogeny[MESH]
  • |Pneumonia, Viral/epidemiology/transmission/virology[MESH]
  • |Recombination, Genetic[MESH]
  • |SARS-CoV-2[MESH]
  • |Sequence Alignment[MESH]
  • |Spike Glycoprotein, Coronavirus/chemistry/genetics[MESH]
  • |Zoonoses/virology[MESH]

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  • suck abstract from ncbi

    282 7815.583 2020