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  • Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis #MMPMID32217650
  • Guan WJ; Liang WH; Zhao Y; Liang HR; Chen ZS; Li YM; Liu XQ; Chen RC; Tang CL; Wang T; Ou CQ; Li L; Chen PY; Sang L; Wang W; Li JF; Li CC; Ou LM; Cheng B; Xiong S; Ni ZY; Xiang J; Hu Y; Liu L; Shan H; Lei CL; Peng YX; Wei L; Liu Y; Hu YH; Peng P; Wang JM; Liu JY; Chen Z; Li G; Zheng ZJ; Qiu SQ; Luo J; Ye CJ; Zhu SY; Cheng LL; Ye F; Li SY; Zheng JP; Zhang NF; Zhong NS; He JX
  • Eur Respir J 2020[May]; 55 (5): ä PMID32217650show ga
  • BACKGROUND: The coronavirus disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. OBJECTIVE: To evaluate the risk of serious adverse outcomes in patients with COVID-19 by stratifying the comorbidity status. METHODS: We analysed data from 1590 laboratory confirmed hospitalised patients from 575 hospitals in 31 provinces/autonomous regions/provincial municipalities across mainland China between 11 December 2019 and 31 January 2020. We analysed the composite end-points, which consisted of admission to an intensive care unit, invasive ventilation or death. The risk of reaching the composite end-points was compared according to the presence and number of comorbidities. RESULTS: The mean age was 48.9 years and 686 (42.7%) patients were female. Severe cases accounted for 16.0% of the study population. 131 (8.2%) patients reached the composite end-points. 399 (25.1%) reported having at least one comorbidity. The most prevalent comorbidity was hypertension (16.9%), followed by diabetes (8.2%). 130 (8.2%) patients reported having two or more comorbidities. After adjusting for age and smoking status, COPD (HR (95% CI) 2.681 (1.424-5.048)), diabetes (1.59 (1.03-2.45)), hypertension (1.58 (1.07-2.32)) and malignancy (3.50 (1.60-7.64)) were risk factors of reaching the composite end-points. The hazard ratio (95% CI) was 1.79 (1.16-2.77) among patients with at least one comorbidity and 2.59 (1.61-4.17) among patients with two or more comorbidities. CONCLUSION: Among laboratory confirmed cases of COVID-19, patients with any comorbidity yielded poorer clinical outcomes than those without. A greater number of comorbidities also correlated with poorer clinical outcomes.
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/diagnosis/*epidemiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/*epidemiology[MESH]
  • |Prognosis[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]

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  • suck abstract from ncbi

    ä 5.55 2020