Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1152/physrev.00013.2020 http://scihub22266oqcxt.onion/10.1152/physrev.00013.2020 32216698!7191627!32216698     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rev 2020 ; 100 (3): 1065-1075 Nephropedia Template TP {{tp|p=32216698|t=2020. Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility |pdf=|usr=}}{{32216698}} gab.com Text Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility JO: Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=32216698 #FOAvip Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyperfibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19. Twit Text FOAVip Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility ????Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=32216698 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32216698 #FOAvip English Wikipedia <ref>{{Cite pmid|32216698}}</ref> Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility #MMPMID32216698 Ji HL; Zhao R; Matalon S; Matthay MA Physiol Rev 2020[Jul]; 100 (3): 1065-1075 PMID32216698show ga Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyperfibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19. |Betacoronavirus/metabolism/pathogenicity[MESH] |COVID-19[MESH] |Comorbidity[MESH] |Coronavirus Infections/*blood/epidemiology/mortality/physiopathology[MESH] |Disease Susceptibility/*blood[MESH] |Fibrinolysin/*metabolism[MESH] |Host-Pathogen Interactions/*physiology[MESH] |Humans[MESH] |Pandemics[MESH] |Plasminogen/*metabolism[MESH] |Pneumonia, Viral/*blood/epidemiology/mortality/physiopathology[MESH] |Respiratory Distress Syndrome/blood/physiopathology/virology[MESH] |Risk Factors[MESH]Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibi(epmc).pdf DeepDyve Pubget Overpricing