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10.3201/eid2606.200037

http://scihub22266oqcxt.onion/10.3201/eid2606.200037
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32213260!7258456!32213260
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suck abstract from ncbi

pmid32213260
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  • Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome #MMPMID32213260
  • Kain T; Lindsay PJ; Adhikari NKJ; Arabi YM; Van Kerkhove MD; Fowler RA
  • Emerg Infect Dis 2020[Jun]; 26 (6): 1102-1112 PMID32213260show ga
  • Available animal and cell line models have suggested that specific therapeutics might be effective in treating Middle East respiratory syndrome (MERS). We conducted a systematic review of evidence for treatment with pharmacologic and supportive therapies. We developed a protocol and searched 5 databases for studies describing treatment of MERS and deaths in MERS patients. Risk of bias (RoB) was assessed by using ROBINS-I tool. We retrieved 3,660 unique citations; 20 observational studies met eligibility, and we studied 13 therapies. Most studies were at serious or critical RoB; no studies were at low RoB. One study, at moderate RoB, showed reduced mortality rates in severe MERS patients with extracorporeal membrane oxygenation; no other studies showed a significant lifesaving benefit to any treatment. The existing literature on treatments for MERS is observational and at moderate to critical RoB. Clinical trials are needed to guide treatment decisions.
  • |*Middle East Respiratory Syndrome Coronavirus[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Coronavirus Infections/*drug therapy/virology[MESH]
  • |Humans[MESH]


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  • suck abstract from ncbi

    1102 6.26 2020