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Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses #MMPMID32205350
Ekins S; Madrid PB
Antimicrob Agents Chemother 2020[Apr]; 64 (5): ä PMID32205350show ga
Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola virus. After a broad screening of additional viruses, we now describe in vitro activity against Chikungunya virus (CHIK) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV).