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10.1016/j.ijantimicag.2020.105949

http://scihub22266oqcxt.onion/10.1016/j.ijantimicag.2020.105949
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32205204!7102549!32205204
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suck abstract from ncbi


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pmid32205204      Int+J+Antimicrob+Agents 2020 ; 56 (1): 105949
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  • Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial #MMPMID32205204
  • Gautret P; Lagier JC; Parola P; Hoang VT; Meddeb L; Mailhe M; Doudier B; Courjon J; Giordanengo V; Vieira VE; Tissot Dupont H; Honore S; Colson P; Chabriere E; La Scola B; Rolain JM; Brouqui P; Raoult D
  • Int J Antimicrob Agents 2020[Jul]; 56 (1): 105949 PMID32205204show ga
  • BACKGROUND: Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the effect of hydroxychloroquine on respiratory viral loads. PATIENTS AND METHODS: French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16(th), to receive 600mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point. RESULTS: Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms. Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported in the litterature for untreated patients. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination. CONCLUSION: Despite its small sample size, our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |Azithromycin/*administration & dosage[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*administration & dosage[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |Polymerase Chain Reaction[MESH]
  • |SARS-CoV-2[MESH]


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