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10.1038/s41423-020-0400-4

http://scihub22266oqcxt.onion/10.1038/s41423-020-0400-4
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32203189!7091888!32203189
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suck abstract from ncbi


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pmid32203189      Cell+Mol+Immunol 2020 ; 17 (6): 613-620
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  • Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine #MMPMID32203189
  • Tai W; He L; Zhang X; Pu J; Voronin D; Jiang S; Zhou Y; Du L
  • Cell Mol Immunol 2020[Jun]; 17 (6): 613-620 PMID32203189show ga
  • The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as 2019 novel coronavirus (2019-nCoV). The CoV spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. Here, we identified the receptor-binding domain (RBD) in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and, hence, attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells, thus inhibiting their infection to host cells. SARS-CoV RBD-specific antibodies could cross-react with SARS-CoV-2 RBD protein, and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2, suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection.
  • |*Viral Vaccines/immunology/metabolism[MESH]
  • |Amino Acid Sequence[MESH]
  • |Animals[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |Betacoronavirus/immunology/*metabolism[MESH]
  • |Binding Sites[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Chiroptera[MESH]
  • |Coronavirus Infections/immunology/metabolism/prevention & control/therapy/*virology[MESH]
  • |Cross Reactions[MESH]
  • |HEK293 Cells[MESH]
  • |Humans[MESH]
  • |Mice[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/immunology/metabolism/therapy/*virology[MESH]
  • |Protein Binding[MESH]
  • |Receptor, Angiotensin, Type 2/*metabolism[MESH]
  • |SARS-CoV-2[MESH]
  • |Sequence Alignment[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/immunology/metabolism[MESH]
  • |Spike Glycoprotein, Coronavirus/*metabolism[MESH]


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