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10.1111/imm.13195 http://scihub22266oqcxt.onion/10.1111/imm.13195 32196653!7218407!32196653     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunology 2020 ; 160 (2): 171-182 Nephropedia Template TP {{tp|p=32196653|t=2020. Respiratory microbiome and epithelial interactions shape immunity in the lungs |pdf=|usr=}}{{32196653}} gab.com Text Respiratory microbiome and epithelial interactions shape immunity in the lungs JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=32196653 #FOAvip The airway epithelium represents a physical barrier to the external environment acting as the first line of defence against potentially harmful environmental stimuli including microbes and allergens. However, lung epithelial cells are increasingly recognized as active effectors of microbial defence, contributing to both innate and adaptive immune function in the lower respiratory tract. These cells express an ample repertoire of pattern recognition receptors with specificity for conserved microbial and host motifs. Modern molecular techniques have uncovered the complexity of the lower respiratory tract microbiome. The interaction between the microbiota and the airway epithelium is key to understanding how stable immune homeostasis is maintained. Loss of epithelial integrity following exposure to infection can result in the onset of inflammation in susceptible individuals and may culminate in lung disease. Here we discuss the current knowledge regarding the molecular and cellular mechanisms by which the pulmonary epithelium interacts with the lung microbiome in shaping immunity in the lung. Specifically, we focus on the interactions between the lung microbiome and the cells of the conducting airways in modulating immune cell regulation, and how defects in barrier structure and function may culminate in lung disease. Understanding these interactions is fundamental in the search for more effective therapies for respiratory diseases. Twit Text FOAVip Respiratory microbiome and epithelial interactions shape immunity in the lungs ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=32196653 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32196653 #FOAvip English Wikipedia <ref>{{Cite pmid|32196653}}</ref> Respiratory microbiome and epithelial interactions shape immunity in the lungs #MMPMID32196653 Invernizzi R; Lloyd CM; Molyneaux PL Immunology 2020[Jun]; 160 (2): 171-182 PMID32196653show ga The airway epithelium represents a physical barrier to the external environment acting as the first line of defence against potentially harmful environmental stimuli including microbes and allergens. However, lung epithelial cells are increasingly recognized as active effectors of microbial defence, contributing to both innate and adaptive immune function in the lower respiratory tract. These cells express an ample repertoire of pattern recognition receptors with specificity for conserved microbial and host motifs. Modern molecular techniques have uncovered the complexity of the lower respiratory tract microbiome. The interaction between the microbiota and the airway epithelium is key to understanding how stable immune homeostasis is maintained. Loss of epithelial integrity following exposure to infection can result in the onset of inflammation in susceptible individuals and may culminate in lung disease. Here we discuss the current knowledge regarding the molecular and cellular mechanisms by which the pulmonary epithelium interacts with the lung microbiome in shaping immunity in the lung. Specifically, we focus on the interactions between the lung microbiome and the cells of the conducting airways in modulating immune cell regulation, and how defects in barrier structure and function may culminate in lung disease. Understanding these interactions is fundamental in the search for more effective therapies for respiratory diseases. |Adaptive Immunity[MESH] |Airway Remodeling/immunology[MESH] |Epithelial Cells/*immunology[MESH] |Homeostasis/immunology[MESH] |Host-Pathogen Interactions/immunology[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Immunity, Mucosal[MESH] |Lung Diseases/*immunology/microbiology[MESH] |Lung/cytology/*immunology/microbiology[MESH] |Microbiota/*immunology[MESH]Respiratory microbiome and epithelial interactions shape immunity in t(epmc).pdf DeepDyve Pubget Overpricing