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10.1002/jmv.25770

http://scihub22266oqcxt.onion/10.1002/jmv.25770
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32181911!7228247!32181911
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suck abstract from ncbi


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pmid32181911      J+Med+Virol 2020 ; 92 (7): 791-796
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  • Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19 #MMPMID32181911
  • Gao Y; Li T; Han M; Li X; Wu D; Xu Y; Zhu Y; Liu Y; Wang X; Wang L
  • J Med Virol 2020[Jul]; 92 (7): 791-796 PMID32181911show ga
  • The role of clinical laboratory data in the differential diagnosis of the severe forms of COVID-19 has not been definitely established. The aim of this study was to look for the warning index in severe COVID-19 patients. We investigated 43 adult patients with COVID-19. The patients were classified into mild group (28 patients) and severe group (15 patients). A comparison of the hematological parameters between the mild and severe groups showed significant differences in interleukin-6 (IL-6), d-dimer (d-D), glucose, thrombin time, fibrinogen, and C-reactive protein (P < .05). The optimal threshold and area under the receiver operator characteristic curve (ROC) of IL-6 were 24.3 and 0.795 microg/L, respectively, while those of d-D were 0.28 and 0.750 microg/L, respectively. The area under the ROC curve of IL-6 combined with d-D was 0.840. The specificity of predicting the severity of COVID-19 during IL-6 and d-D tandem testing was up to 93.3%, while the sensitivity of IL-6 and d-D by parallel test in the severe COVID-19 was 96.4%. IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Area Under Curve[MESH]
  • |Betacoronavirus/genetics/*pathogenicity[MESH]
  • |Biomarkers/blood[MESH]
  • |Blood Glucose/metabolism[MESH]
  • |C-Reactive Protein/metabolism[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Cardiovascular Diseases/blood/complications/*diagnosis/pathology[MESH]
  • |Clinical Laboratory Techniques/methods[MESH]
  • |Coronavirus Infections/blood/complications/*diagnosis/pathology[MESH]
  • |Diabetes Complications/blood[MESH]
  • |Diabetes Mellitus/blood/*diagnosis/pathology[MESH]
  • |Female[MESH]
  • |Fibrin Fibrinogen Degradation Products/*metabolism[MESH]
  • |Fibrinogen/metabolism[MESH]
  • |Humans[MESH]
  • |Interleukin-6/*blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/complications/*diagnosis/pathology[MESH]
  • |Pulmonary Disease, Chronic Obstructive/blood/complications/*diagnosis/pathology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Sensitivity and Specificity[MESH]
  • |Severity of Illness Index[MESH]


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