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10.1016/j.tmaid.2020.101623

http://scihub22266oqcxt.onion/10.1016/j.tmaid.2020.101623
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32179124!7102608!32179124
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suck abstract from ncbi


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pmid32179124      Travel+Med+Infect+Dis 2020 ; 34 (ä): 101623
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  • Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis #MMPMID32179124
  • Rodriguez-Morales AJ; Cardona-Ospina JA; Gutierrez-Ocampo E; Villamizar-Pena R; Holguin-Rivera Y; Escalera-Antezana JP; Alvarado-Arnez LE; Bonilla-Aldana DK; Franco-Paredes C; Henao-Martinez AF; Paniz-Mondolfi A; Lagos-Grisales GJ; Ramirez-Vallejo E; Suarez JA; Zambrano LI; Villamil-Gomez WE; Balbin-Ramon GJ; Rabaan AA; Harapan H; Dhama K; Nishiura H; Kataoka H; Ahmad T; Sah R
  • Travel Med Infect Dis 2020[Mar]; 34 (ä): 101623 PMID32179124show ga
  • INTRODUCTION: An epidemic of Coronavirus Disease 2019 (COVID-19) began in December 2019 in China leading to a Public Health Emergency of International Concern (PHEIC). Clinical, laboratory, and imaging features have been partially characterized in some observational studies. No systematic reviews on COVID-19 have been published to date. METHODS: We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. Observational studies and also case reports, were included, and analyzed separately. We performed a random-effects model meta-analysis to calculate pooled prevalences and 95% confidence intervals (95%CI). RESULTS: 660 articles were retrieved for the time frame (1/1/2020-2/23/2020). After screening, 27 articles were selected for full-text assessment, 19 being finally included for qualitative and quantitative analyses. Additionally, 39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI 84.5-92.9%), cough (57.6%, 95%CI 40.8-74.4%) and dyspnea (45.6%, 95%CI 10.9-80.4%) were the most prevalent manifestations. Among the patients, 20.3% (95%CI 10.0-30.6%) required intensive care unit (ICU), 32.8% presented with acute respiratory distress syndrome (ARDS) (95%CI 13.7-51.8), 6.2% (95%CI 3.1-9.3) with shock. Some 13.9% (95%CI 6.2-21.5%) of hospitalized patients had fatal outcomes (case fatality rate, CFR). CONCLUSION: COVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities. ICU was required for approximately 20% of polymorbid, COVID-19 infected patients and hospitalization was associated with a CFR of >13%. As this virus spreads globally, countries need to urgently prepare human resources, infrastructure and facilities to treat severe COVID-19.
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*diagnosis/pathology[MESH]
  • |Cough/virology[MESH]
  • |Fever/virology[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Intensive Care Units[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis/pathology[MESH]
  • |Respiratory Distress Syndrome/virology[MESH]


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