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10.1016/j.cca.2020.03.022

http://scihub22266oqcxt.onion/10.1016/j.cca.2020.03.022
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32178975!7102663!32178975
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suck abstract from ncbi

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  • Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis #MMPMID32178975
  • Lippi G; Plebani M; Henry BM
  • Clin Chim Acta 2020[Jul]; 506 (ä): 145-148 PMID32178975show ga
  • BACKGROUND: Coronavirus disease 2019 (COVID-19) is a novel infectious disease with lack of established laboratory markers available to evaluate illness severity. In this study, we investigate whether platelet count could differentiate between COVID-19 patients with or without severe disease. Additionally, we evaluate if thrombocytopenia is associated with severe COVID-19. METHODS: An electronic search in Medline, Scopus and Web of Science was performed to identify studies reporting data on platelet count in COVID-19 patients. A meta-analysis was performed, with calculation of weighted mean difference (WMD) of platelet number in COVID-19 patients with or without severe disease and odds ratio (OR) of thrombocytopenia for severe form of COVID-19. RESULTS: Nine studies with 1779 COVID-19 patients, 399 (22.4%) with severe disease, were included in the meta-analysis. The pooled analysis revealed that platelet count was significantly lower in patients with more severe COVID-19 (WMD -31 x 10(9)/L; 95% CI, from -35 to -29 x 10(9)/L). A subgroup analysis comparing patients by survival, found an even lower platelet count was observed with mortality (WMD, -48 x 10(9)/L; 95% CI, -57 to -39 x 10(9)/L. In the four studies (n = 1427) which reported data on rate of thrombocytopenia, a low platelet count was associated with over fivefold enhanced risk of severe COVID-19 (OR, 5.1; 95% CI, 1.8-14.6). CONCLUSIONS: Low platelet count is associated with increased risk of severe disease and mortality in patients with COVID-19, and thus should serve as clinical indicator of worsening illness during hospitalization.
  • |Betacoronavirus/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*blood/*complications[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Platelet Count[MESH]
  • |Pneumonia, Viral/*blood/*complications[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Thrombocytopenia/*blood/*etiology[MESH]


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  • suck abstract from ncbi

    145 ä.506 2020