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10.1016/j.jmii.2020.03.002

http://scihub22266oqcxt.onion/10.1016/j.jmii.2020.03.002
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suck abstract from ncbi


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pmid32178970      J+Microbiol+Immunol+Infect 2020 ; 53 (3): 419-424
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  • Composition of human-specific slow codons and slow di-codons in SARS-CoV and 2019-nCoV are lower than other coronaviruses suggesting a faster protein synthesis rate of SARS-CoV and 2019-nCoV #MMPMID32178970
  • Yang CW; Chen MF
  • J Microbiol Immunol Infect 2020[Jun]; 53 (3): 419-424 PMID32178970show ga
  • Translation of a genetic codon without a cognate tRNA gene is affected by both the cognate tRNA availability and the interaction with non-cognate isoacceptor tRNAs. Moreover, two consecutive slow codons (slow di-codons) lead to a much slower translation rate. Calculating the composition of host specific slow codons and slow di-codons in the viral protein coding sequences can predict the order of viral protein synthesis rates between different virus strains. Comparison of human-specific slow codon and slow di-codon compositions in the genomes of 590 coronaviruses infect humans revealed that the protein synthetic rates of 2019 novel coronavirus (2019-nCoV) and severe acute respiratory syndrome-related coronavirus (SARS-CoV) may be much faster than other coronaviruses infect humans. Analysis of host-specific slow codon and di-codon compositions provides links between viral genomic sequences and capability of virus replication in host cells that may be useful for surveillance of the transmission potential of novel viruses.
  • |Betacoronavirus/*genetics[MESH]
  • |Codon/*genetics[MESH]
  • |Genome, Viral/genetics[MESH]
  • |Humans[MESH]
  • |Phylogeny[MESH]
  • |Protein Biosynthesis/*genetics[MESH]
  • |RNA, Transfer/genetics[MESH]
  • |SARS-CoV-2[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/*genetics[MESH]


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