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10.1080/22221751.2020.1739565 http://scihub22266oqcxt.onion/10.1080/22221751.2020.1739565 32178593!7103712!32178593     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32178593&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Emerg+Microbes+Infect 2020 ; 9 (1): 601-604 Nephropedia Template TP {{tp|p=32178593|t=2020. Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 |pdf=|usr=}}{{32178593}} gab.com Text Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32178593 #FOAvip The recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free) and open (ligand-bound) conformation, which is involved in host cell adhesion. We also predict the unique N- and O-linked glycosylation sites of spike glycoprotein that distinguish it from the SARS and underlines shielding and camouflage of COVID-19 from the host the defence system. Furthermore, our study also highlights the key finding that the S1 domain of COVID-19 spike glycoprotein potentially interacts with the human CD26, a key immunoregulatory factor for hijacking and virulence. These findings accentuate the unique features of COVID-19 and assist in the development of new therapeutics. Twit Text FOAVip Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32178593 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32178593 #FOAvip English Wikipedia <ref>{{Cite pmid|32178593}}</ref> Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 #MMPMID32178593 Vankadari N; Wilce JA Emerg Microbes Infect 2020[]; 9 (1): 601-604 PMID32178593show ga The recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free) and open (ligand-bound) conformation, which is involved in host cell adhesion. We also predict the unique N- and O-linked glycosylation sites of spike glycoprotein that distinguish it from the SARS and underlines shielding and camouflage of COVID-19 from the host the defence system. Furthermore, our study also highlights the key finding that the S1 domain of COVID-19 spike glycoprotein potentially interacts with the human CD26, a key immunoregulatory factor for hijacking and virulence. These findings accentuate the unique features of COVID-19 and assist in the development of new therapeutics. |Betacoronavirus/chemistry/genetics/*metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/virology[MESH] |Dipeptidyl Peptidase 4/*chemistry/metabolism[MESH] |Humans[MESH] |Models, Molecular[MESH] |Pandemics[MESH] |Pneumonia, Viral/virology[MESH] |Polysaccharides/*chemistry/metabolism[MESH] |Protein Binding[MESH] |Protein Structure, Quaternary[MESH] |SARS-CoV-2[MESH]Emerging WuHan (COVID-19) coronavirus: glycan shield and structure pre(epmc).pdf DeepDyve Pubget Overpricing